Research Article
Volume 7 Issue 9 - 2018
Short Term Effects of Nebulized Epinephrine as a Treatment of Viral Bronchiolitis
Osama Moustafa Zayed1*, Badr El-deen Mohamad Mesbah2, Hoda Ahmed Atwa2, Nesreen Mosad Handooka2 and Monira Taha Ismael1
1Department of Emergency Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Paediatrics and Neonatology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
*Corresponding Author: Osama Moustafa Zayed, Department of Emergency Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Received: May 08, 2018; Published: August 20, 2018
Citation: Osama Moustafa Zayed., et al. “Short Term Effects of Nebulized Epinephrine as a Treatment of Viral Bronchiolitis”. EC Pulmonology and Respiratory Medicine 7.9 (2018): 620-624.
Objective: To assess short term effects of nebulized epinephrine on heart rate, clinical score and oxygen saturation.
Patients and Methods: Prospective, randomized, controlled study to determine if there is adverse effects of using nebulized epinephrine in treatment of infants suffering from bronchiolitis, 96 infant were enrolled in the study divided to 3 groups randomly, first group received nebulized hypertonic saline 3% only (placebo group), second group received nebulized hypertonic saline 3% with 1:1000 epinephrine, and third group received normal saline 0.9% with 1:1000 epinephrine. Patients’ heart rate, oxygen saturation and clinical scores were recorded before treatment and after each nebulizer they received at 30, 60, 90 and 120 minutes. Comparison of the three groups was done by SPSS Kruskal Wallis test and ANOVA.
Results: We found that epinephrine didn’t cause increase in heart rate compared to placebo group, change of heart rate was almost equal in the three groups with a p-value of 0.898. Change of clinical severity score and oxygen saturation was also similar in both epinephrine group and placebo group with no significant difference p-value = 0.868 and 0.452 respectively.
Conclusion: Nebulized epinephrine doesn’t increase heart rate and can be used safely in treating infants with bronchiolitis.
Keywords: Bronchiolitis; Nebulized Epinephrine
Copyright: © 2018 Osama Moustafa Zayed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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