Review Article
Volume 7 Issue 8 - 2018
Natural Products a Reservoir of Drugs for Treatment of Pulmonary Tuberculosis
Grace Chitima Mugumbate*, Lorraine Yamurai Bishi and Freeborn Rwere
Department of Chemistry, School of Natural Sciences and Mathematics, Chinhoyi University of Technology, Chinhoyi, Zimbabwe
*Corresponding Author: Grace Chitima Mugumbate, Department of Chemistry, School of Natural Sciences and Mathematics, Chinhoyi University of Technology, Chinhoyi, Zimbabwe. E-Mail: gmugumbate@cut.ac.zw
Received: June 21, 2018; Published: July 09, 2018
Citation: Grace Chitima Mugumbate., et al. “Natural Products a Reservoir of Drugs for Treatment of Pulmonary Tuberculosis”. EC Pulmonology and Respiratory Medicine 7.8 (2018): 545-553.
Abstract
Tuberculosis continues to cause health havoc worldwide, more than 90% of the reported cases are due to pulmonary tuberculosis. The treatment of tuberculosis was under control for decades; however this was challenged by the rapid emergence of multidrug, extreme and recently total drug resistant strains of Mycobacterium tuberculosis, the causative agent of the disease. Therefore researchers are urgently hunting for new chemical entities that can be used in the development of novel tuberculosis drugs and also in identification of their targets. This review gives an overview of the current drugs used in pulmonary chemotherapy, current challenges, natural products as sources for novel anti-tuberculosis compounds, and the importance of the mode of action and the targets for the natural products. A focus on natural products would encourage researchers to revisit nature for the much needed novel drugs for treatment of pulmonary tuberculosis.
Keywords: Natural Products; Pulmonary Tuberculosis; Drug Resistance; Targets
Copyright: © 2018 Grace Chitima Mugumbate., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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