Research Article
Volume 7 Issue 8 - 2018
Multi Drug Resistant Tuberculosis an Emerging Concern a Study at Tertiary Health Center in Nigeria
Jacob A Dunga1*, Sabiu A Gwalabe1, Nura H Alkali1, Yusuf Y Jibrin1, Mohammed Alkali1, Yakubu Adamu2, Mustapha S Umar1, Jafiada J Musa1, Adebola Lawanson2, Babawale Victor A2, Sulaiman Y Yerima4, Sati K Awang4, Ababakar A Gombe5, Aderonke Agbaji6, Vivian Ibeziako6, Samuel Ogiri7, Shamaki R Baba1, Murtala Umar1, Ojo Temitope1 and Abdulwahab Lasisi1
1Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) Bauchi, Nigeria
2United State Department of Defense (USDOD) Walter Reed Program Abuja, Nigeria
3National Tuberculosis and Leprosy control program (NTBLCP) Abuja, Nigeria
4Federal Medical Center Yola, Nigeria
5Federal Teaching Hospital Gombe, Nigeria
6Institute of Human Virology Nigeria (IHVN), Nigeria
7World Health Organization (WHO), Abuja, Nigeria
*Corresponding Author: Jacob A Dunga, Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH) Bauchi, Nigeria.
Received: June 11, 2018; Published: July 06, 2018
Citation: Jacob A Dunga., et al. “Multi Drug Resistant Tuberculosis an Emerging Concern a Study at Tertiary Health Center in Nigeria”. EC Pulmonology and Respiratory Medicine 7.8 (2018): 530-538.
Abstract
Background: The emergence and spread of drug-resistant tuberculosis (DR-TB) has become the major concern in global TB control nowadays due to its limited therapy options and high mortality. An evaluation of the epidemiological trends of DR-TB in Abubakar Tafawa Balewa University Teaching Hospital (ATBUTH), Bauchi, of which TB incidences is remarkable, is essential but lacking.
Aim: There has been a steady rise in MDR-TB in Nigeria between 2009 and 2014 and the number of patient enrolled is still well below the estimated 21,000 cases of MDR-TB. Few studies on the trends of MDR-TB was done in Nigeria. This study is center based survey to understand the burden and dynamics of DR-TB for effective planning and positioning of the health care centers in order to mitigate, treat and reduce the burden of DR-TB.
Method: This study is cross sectional study which looked into the presumptive DR-Tb register at the Bacteriology laboratory of ATBUTH for a period of 24 months, between November 2014 to October 2016, patient data for acid fast bacilli (AFB) smear and Xpert MTB/RIF assays were obtained. Socio demographic data including age, sex, were collected and clinical data including treatment history, prior TB contact, cavity, and bilateral disease on chest radiology were available.
Results: Multidrug-resistant TB (MDR-TB) was found to be on the increase with more males (15%) affected compared to female (8%), Majority of the positive cases 8% were among those age 26 - 35 yrs and 2% among the elderly patient age ≥ 55 yrs. 2.3% of the study subject had MDR-TB/HIV co infection. There were more male co infected patients 5.9% compared to female co infected patient 2.6% among the MDR-TB positive subject (P = 0.619). It is essentially an acquired condition, 17% among retreatment compared to 5% among new cases (P = 0.000).
Conclusion: MDR-TB is on the increase it is essentially an acquired condition with mal preponderance, its association with HIV disease is still on the lower side compared to studies in advanced countries poor diagnostic technique for immunocompromised host with pauci bacillary disease could be a factors for low levels noticed in poor countries.
Keywords: MDR-TB; Age; Sex; HIV Co-Morbidity
Copyright: © 2018 Jacob A Dunga., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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