Research Article
Volume 9 Issue 8 - 2020
Findings from a Pilot Study on the Intake of Prebiotics and the Health-Related Quality of Life in a Sample of Young Obese Women
Roland Müller1*, Caroline Liener2, Sophie Cabaset3 and Susanne Maurer1
1Leading Psychologist, Center of Obesity and Metabolism Winterthur GmbH, Winterthur, Switzerland
2OVIVA AG, Zurich, Switzerland
3Bio- Strath® AG, Zurich, Switzerland
*Corresponding Author: Roland Müller, Leading Psychologist, Center of Obesity and Metabolism Winterthur GmbH, Winterthur, Switzerland.
Received: July 01, 2020; Published: July 29, 2020


Background: The microbiome plays an important role in many physical and psychological health conditions. Administration of pre or probiotics leads to improvements in physiological and psychological symptoms, promoting a better health-related quality of life (HRQOL). The current understanding of HRQOL in people with intestinal problems and microbiome dysbiosis defines a twofold model with impairments which can be broadly reduced to psychosocial and gastrointestinal risk factors. Evidence exists that the microbiome also influences physiological conditions which could potentially lead to obesity.

Obese patients suffer from various abdominal complaints, such as abdominal pain, flatulence or changing stool behavior which can affect general well-being and adherence to dietary therapy. The aims of the current study are to explore the potential therapeutic effects of prebiotics on HRQOL in the context of a preliminary interventional study in obese women and to put the study findings into a conceptual framework of administration of pre and probiotics and HRQOL in obesity.

Methods: 26 obese women took a dietary supplement consisting of plasmolyzed herbal baker’s yeast (StrathÒ Original) over a period of three weeks. Food intake was tracked via a smartphone app. HRQOL was assessed before and after the intervention using an adaption of the SF-12 questionnaire.

Results: Though not the primary goal of the study, data indicated changes in some aspects of HRQOL. Change scores and confidence intervals for six aspects of HRQOL were calculated and pre and post measurements were compared using a Wilcoxon Signed Rank Test. Results indicated a small but non-significant trend for improvements in satisfaction with health, general well-being and fatigue after meal intake. Coping with stress, satisfaction with social and occupational life slightly non-significant decreased after the intervention. As anticipated, participants did not lose weight.

Conclusion: Administration of a prebiotic dietary supplement in combination with nutrition- and exercise tracking leads to changes in the overall condition in obese individuals and to a higher problem awareness. The medical as well as psychological therapeutic potential of pre and probiotics should be put into the complex framework of obesity. More detailed and longer-term studies on the influence of pre and probiotics on obesity are needed.  

Keywords: Microbiome; Prebiotics; Obesity; Health-Related Quality Of Life; Yeast Based Supplement


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Citation: Roland Müller., et al. “Findings from a Pilot Study on the Intake of Prebiotics and the Health-Related Quality of Life in a Sample of Young Obese Women”. EC Psychology and Psychiatry 9.8 (2020): 101-114.

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