Research Article
Volume 9 Issue 6 - 2020
Clozapine Protective Effect on Suicide Behavior in Schizophrenics
Daphne Ronacher Dantas Jarczewski and César Augusto Trinta Weber*
Psychiatry Training Program, Jose de Barros Falcão Study Center, Porto Alegre, RS, Brazil
*Corresponding Author: César Augusto Trinta Weber, Medical Psychiatrist. Post-doctorate by the Department of Neuroscience and Behavioral Sciences at Ribeirão Preto Medical School / USP. Technical Director of the Clinical Psychiatry and Psychotherapy Clinic, Scientific Director, Supervisor and advisor of the Psychiatry Training Program at the Jose de Barros Falcão Study Center.
Received: March 30, 2020; Published: May 09, 2020




Abstract

Introduction: The World Health Organization estimates that, by 2020, about 1.5 million people will die of suicide, representing approximately 2.4% of all deaths worldwide. Suicide is highly associated with psychiatric disorders, including schizophrenia.

Objective: To investigate the protective effect of clozapine in a schizophrenic patient with suicidal behavior.

Method: Non-exhaustive narrative review highlighting the main works published since 2011, in the electronic database MEDLINE, by the use of the keywords, in English, "clozapine", "schizophrenia", "risk", "suicide".

Results: Studies have shown that clozapine is a psychopharmacological alternative of a protective effect on the risk of suicide in schizophrenics. Clozapine is the only atypical antipsychotic approved by the FDA with a prophylactic indication in these psychiatric settings.

Keywords: Clozapine; Schizophrenia; Risk; Suicide

References

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  3. Meltzer HY., et al. “Clozapine treatment for suicidality in schizophrenia: international suicide prevention trial (InterSePT)”. Archives of General Psychiatry1 (2003): 82-91.
  4. Martínez-Aguayo JC., et al. “Antipsicóticos y suicidio”. Revista Chilena De Neuro-Psiquiatría 2 (2016): 141-150.
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  6. Warnez S and Alessi-severini S. “Clozapine: a review of clinical practice guidelines and prescribing trends”. BMC Psychiatry 1 (2014): 102.
  7. Patchan KM., et al. “The risk of suicide after clozapine discontinuation: Cause for concern”. Annals of Clinical Psychiatry 4 (2015): 253-256.
  8. Cordioli AV., et al. “Psicofármacos: Consulta Rápida. 5th edition”. Porto Alegre: Artmed Editora (2015).
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  10. Alphs L., et al. “The international suicide prevention trial (interSePT): rationale and design of a trial comparing the relative ability of clozapine and olanzapine to reduce suicidal behavior in schizophrenia and schizoaffective patients”. Schizophrenia Bulletin3 (2004): 577-586.

 

Citation: Daphne Ronacher Dantas Jarczewski and César Augusto Trinta Weber. “Clozapine Protective Effect on Suicide Behavior in Schizophrenics”.EC Psychology and Psychiatry9.6 (2020): 39-45.

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