Research Article
Volume 9 Issue 5 - 2020
Acoustic Startle Response and Prepulse Inhibition: Sex Differences with Cocaine
James R Hordof1 and Patricia A Broderick1,2,3,4*
1Department of Molecular, Cellular and Biomedical Sciences, CUNY School of Medicine, The City University of New York, New York, USA
2Department of Psychology, Cognitive and Behavioral Neuroscience, CUNY Graduate Center, New York, USA
3Department of Biology, CUNY Neuroscience Collaborative Graduate Program, New York, USA
4NYU Langone Medical Center and Epilepsy Center, New York, USA
*Corresponding Author: Patricia A Broderick, Department of Molecular, Cellular and Biomedical Sciences, CUNY School of Medicine, The City University of New York, New York, USA.
Received: March 09, 2020; Published: April 13, 2020


Schizophrenia is a debilitating neurological illness and in this study, our focus is on an aspect of neuro-cognition that is believed to explain many of the attention and cognitive deficits associated with schizophrenia. The acoustic startle response paradigm is applied to the animal model to test the gain or loss of prepulse inhibition (PPI). A decline in prepulse inhibition has been used as a direct correlate of dysfunctional sensorimotor gating which is measured in this study as an increase in startle amplitude or Vmax. With the injection (ip) of cocaine we induced psychosis in male and female murine animals. We compared changes in the acoustic startle response after administration of cocaine using physiological saline as a control. Sex response differences were analyzed with two-way ANOVA PRISM software by Graph Pad and significant differences were found between both dosage variation and gender. Empirical research in our laboratory with Neuromolecular Imaging reveals the pharmacokinetics of cocaine induced sex differences involved in the area of the mesocorticolimbic biogenic amine systems. In previous studies of the acoustic startle paradigm in the Broderick lab, higher doses of cocaine were used. In this investigation, low doses of cocaine were administered to compare to higher doses as different dose responses are seen when studying typical versus atypical antipsychotics. Furthermore, subtle changes and variations of responses between sexes at the lower doses may belie the underpinnings of the mechanism of such an atypical medication, risperidone.

Keywords: Acoustic Startle Response; Prepulse Inhibition; Cocaine Psychosis; Mesocorticolimbic System; Nucleus Accumbens; Schizophrenia; BRODERICK PROBE®


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Citation: James R Hordof and Patricia A Broderick. “Acoustic Startle Response and Prepulse Inhibition: Sex Differences with Cocaine”. EC Psychology and Psychiatry 9.5 (2020): 08-16.

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