Research Article
Volume 9 Issue 3 - 2020
Inflammatory Markers in Patients with Frontotemporal Dementia
Lyubov Androsova2, Natalya Mikhaylova1, Svetlana Zozulya2*, Yana Fedorova1 and Tatyana Klyushnik2
1Department of Geriatric Psychiatry, Mental Health Research Centre, Moscow, Russia
2Laboratory of Neuroimmunology, Mental Health Research Centre, Moscow, Russia
*Corresponding Author: Svetlana Zozulya, Laboratory of Neuroimmunology, Mental Health Research Centre, Moscow, Russia.
Received: January 31, 2020; Published: February 27, 2020




Purpose of the Study: The purpose of this study was to determine a level of inflammation markers in the blood of patients with frontotemporal dementia (FTD).

Materials and Methods: 34 patients with FTD were examined. The diagnosis of FTD was established according to the diagnostic criteria of the International Consortium 2011. The healthy group consisted of 35 people, comparable in age and sex with patients with FTD. Blood plasma was used for immunological studies. The enzymatic activity of leukocyte elastase (LE) and the functional activity of α1-proteinase inhibitor (α1-PI) were determined by spectrophotometric method, the concentration of interleukin-6 (IL-6), C-reactive protein (CRP) and the level of autoantibodies to S100b and myelin basic protein (MBP) were determined by enzyme immunoassay.

Results: Patients with FTD showed a significant increase in the activity of α1-PI compared with the control (p < 0.001). Other indicators did not differ from the control ones. However, a significant variation of all studied parameters was revealed, both the excess of values and their decrease relative to the control. For example, LE activity was from 127 to 276.5 nmol/min·ml. According to this level, two immune phenotypes were identified: 47% of patients with FTD are characterized by a proinflammatory immune phenotype with an increase of inflammatory marker values, and 53% of patients with FTD have proinflammatory immune phenotype with insufficient neutrophil activity (decreased LE activity and increased level of other inflammatory markers). This immune phenotype was similar to that in patients with Alzheimer's disease.

Conclusion: The results obtained indicate the involvement of inflammation in the development of FTD and the immunological heterogeneity of this variant of dementia.

Keywords:Frontotemporal Dementia; Markers of Inflammation; Leukocyte Elastase; Interleukin-6; Acute-Phase Proteins

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Citation: Svetlana Zozulya., et al. “Inflammatory Markers in Patients with Frontotemporal Dementia”. EC Psychology and Psychiatry 9.3 (2020): 01-08.

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