Research Article
Volume 11 Issue 4 - 2022
Association of Oxygen Saturation Index with Oxygenation Index in Neonates with Hypoxemic Respiratory Failure

Amlendra Kumar Yadav1*, Mohammad Kamrul Hassan Shabuj2, Tareq Rahman3, Chit Narayan Sah1, Ismat Jahan3, Sadeka Choudhury Moni4, Sanjoy Kumer Dey5, Mohammod Shahidullah6 and MA Mannan5

1Neonatologist, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh

2Associate Professor, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh

3Assistant Professor, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh

4Associate Professor, Department of Pediatrics, Mugda Medical College and Hospital, Dhaka, Bangladesh

5Professor, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh

6Professor and Chairman, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh

*Corresponding Author: Amlendra Kumar Yadav, Neonatologist, Department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Received: February 18, 2022; Published: March 31, 2022


Background: Hypoxemic respiratory failure is a deficiency of oxygenation associated with insufficient ventilation. Oxygenation index describes the severity of this condition. However, it requires invasive and expert hand required for arterial access. Oxygen saturation index is non-invasive and allows continuous monitoring of oxygenation status with pulse oximeter and no expert hand required.

Objectives: To determine the association between oxygenation index (OI) with oxygen saturation index (OSI).

Methodology: This cross-sectional study was conducted from September 2019 to February 2020 at department of Neonatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Results: A total of 103 OI and OSI measurements were calculated from 33 neonates (26 Preterm and 7 Term) with 21.2% appropriate for gestational age and 78.2% low birth weight were recorded during the study. OI and OSI showed a significant correlation (r = 0.69). The predictive derivative equation had a significant linear association between measured OI and derived OI, AUC 0.94 with 94% sensitivity and 81% sensitivity over cutoff value ≥ 5 between measured OI and derived OI. Comparison between the mean of measured OI and derived OI with the difference between measured OI and derived OI showed good agreement with mean value 0.49 and limits of agreement between 6.33 and -5.33.

Conclusion: This study showed a significant correlation of oxygenation index with oxygen saturation index. OSI may be used to assess the severity of hypoxemic respiratory failure in neonates without arterial access.


Keywords: Oxygenation index; Oxygen Saturation Index; Hypoxemic Respiratory Failure


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Citation: Amlendra Kumar Yadav., et al. “Association of Oxygen Saturation Index with Oxygenation Index in Neonates with Hypoxemic Respiratory Failure”. EC Paediatrics 11.4 (2022): 140-150.

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