Review Article
Volume 11 Issue 4 - 2022
Surfactant Administration through Laryngeal Supra Glottic Airway Technique in Preterm Babies; A New Era Waiting Exploration
Saima Asghar*
Consultant Pediatrics And Neonatology, Zubaida Memorial Hospital, Pakistan
*Corresponding Author: Saima Asghar, Consultant Pediatrics And Neonatology, Zubaida Memorial Hospital, Pakistan.
Received: February 28, 2022; Published:March 30, 2022


Respiratory distress syndrome (RDS) is common morbidity in pre term babies. Treatment involves antenatal corticosteroids, respiratory support and exogenous surfactant therapy. Surfactant therapy has undergone evolution over time. Supra-glottic air way devices (SAD) like laryngeal mask air way (LMA) is emerging a safer and better option. This review article aims to review supra glottic air way devices like LMA use to provide eminent therapy to pre term babies.


Keywords: Respiratory Distress Syndrome (RDS); Less Invasive Surfactant Administration (LISA); Minimal Invasive Surfactant Administration (MISA); Surfactant Administration Through Laryngeal Supra Glottic Air Way (SALSA); Supra Glottic Airway Devices (SAD); Silverman-Anderson Score (SAS)


  1. Najafian Bita and Khosravi Mohammad. "Neonatal Respiratory Distress Syndrome: Things to Consider and Ways to Manage". Update on Critical Issues on Infant and Neonatal Care, edited by René Barría, IntechOpen (2020).
  2. Yadav S., et al. “Neonatal Respiratory Distress Syndrome”. In: StatPearls. Treasure Island (FL): StatPearls Publishing (2021).
  3. Roberts CT., et al. “Supraglottic airway devices for administration of surfactant to newborn infants with respiratory distress syndrome: a narrative review”. Archives of Disease in Childhood: Fetal and Neonatal Edition3 (2021): 336-341.
  4. Roth-Kleiner M and Post M. “Similarities and dissimilarities of branching and septation during lung development”. Pediatric Pulmonology2 (2005): 113-134.
  5. Herriges M and Morrisey EE. “Lung development: orchestrating the generation and regeneration of a complex organ”. Development3 (2014): 502-513.
  6. Gao Y., et al. “Unique aspects of the developing lung circulation: structural development and regulation of vasomotor tone”. Pulmonary Circulation4 (2016): 407-425.
  7. Hibbard JU., et al. “Respiratory morbidity in late preterm births. Consortium on Safe Labor”. The Journal of the American Medical Association4 (2010): 419-425.
  8. Li Y Gregory K., et al. “Maternal diabetes mellitus and risk of neonatal respiratory distress syndrome: a meta-analysis”. Acta Diabetologica7 (2019): 729-740.
  9. Grappone L and Messina F. “Hyaline membrane disease or respiratory distress syndrome? A new approach for an old disease”. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)2 (2014): e030263.
  10. Hedstrom Anna Bruett., et al. “Performance of the Silverman Andersen Respiratory Severity Score in predicting PCO2 and respiratory support in newborns: a prospective cohort study”. Journal of Perinatology: Official Journal of the California Perinatal Association5 (2018): 505-511.
  11. Sweet DG., et al. “European consensus guidelines on the management of neonatal respiratory distress syndrome in preterm infants-2013 update”. Neonatology4 (2013): 353-368.
  12. Viteri OA., et al. “Antenatal Corticosteroids for the Prevention of Respiratory Distress Syndrome in Premature Twins”. Obstetrics and Gynecology3 (2016): 583-591.
  13. CJ Davis PG., et al. “Nasal CPAP or intubation at birth for very preterm infants”. The New England Journal of Medicine7 (2008): 700-708.
  14. Bancalari E and Claure N. “The evidence for non-invasive ventilation in the preterm infant”. Archives of Disease in Childhood - Fetal and Neonatal Edition2 (2013): F98-F102.
  15. Gerber A Gregory K., et al. “Incidence and outcome of CPAP failure in preterm infants”. Pediatrics1 (2016): e20153985.
  16. Sood BG., et al. “Aerosolized surfactant in neonatal respiratory distress syndrome: Phase I study”. Early Human Development 134 (2019): 19-25.
  17. Singh N., et al. “Comparison of animal-derived surfactants for the prevention and treatment of respiratory distress syndrome in preterm infants”. Cochrane Database of Systematic Reviews 12 (2015): CD010249.
  18. Dargaville PA., et al. “Preliminary evaluation of a new technique of minimally invasive surfactant therapy”. Archives of Disease in Childhood: Fetal and Neonatal Edition4 (2011): F243-248.
  19. Abdel-Latif ME and Osborn DA. “Laryngeal mask airway surfactant administration for prevention of morbidity and mortality in preterm infants with or at risk of respiratory distress syndrome”. Cochrane Database of Systematic Reviews 7 (2011): CD008309.
  20. Göpel W., et al. “German Neonatal Network. Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial”. Lancet9803 (2011): 1627-1634.
  21. Pinheiro JM., et al. “Randomized trial of laryngeal mask airway versus endotracheal intubation for surfactant delivery”. Journal of Perinatology3 (2016): 196-201.
  22. Minocchieri S., et al. “Nebulised surfactant to reduce severity of respiratory distress: a blinded, parallel, randomised controlled trial”. Archives of Disease in Childhood: Fetal and Neonatal Edition3 (2019): F313-F319.
  23. Marshall TA., et al. “Physiologic changes associated with endotracheal intubation in preterm infants”. Critical Care Medicine 12 (1984): 501-503.
  24. Attridge JT., et al. “Administration of rescue surfactant by laryngeal mask airway: lessons from a pilot trial”. American Journal of Perinatology3 (2013): 201-206.
  25. Kaushal M., et al. “Surfactant administration through laryngeal supraglottic airway (SALSA): A unique and new technique of surfactant administration”. Edorium™ Journal of Maternal and Child Health 5 (2020): 100008M01MK2020.
  26. Al Ali., et al. “Laryngeal Mask Airway for Surfactant Administration Versus Standard Treatment Methods in Preterm Neonates with Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis”. American Journal of Perinatology (2021).
Citation: Saima Asghar. “Surfactant Administration through Laryngeal Supra Glottic Airway Technique in Preterm Babies; A New Era Waiting Exploration”. EC Paediatrics 11.4 (2022): 58-63.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

February Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the February issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 17, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.