Research Article
Volume 11 Issue 4 - 2022
Evaluation of Serum Ascorbic, Pantothenic Acid Level and Full Blood Count among Plasmodium Parasitized Pregnant Women in Sokoto Specialist Hospital, Sokoto, Nigeria
Erhabor Osaro1*, Sulaiman Sule Umar1, Dangana Amos2, Erhabor Tosan3, Adias Teddy Charles4 and Egenti Bibiana Nonye5
1Department of Haematology, School of Medical Laboratory Science, College of Health Sciences Usmanu Danfodiyo University Sokoto, Nigeria
2Department of Haematology, University of Abuja Teaching Hospital Gwagwalada, Abuja, Nigeria
3Medical Laboratory Science Council of Nigeria, Nigeria
4Federal University Otuoke, Bayelsa State, Nigeria
5Department of Community Medicine, College of Health Sciences, University of Abuja, Nigeria
*Corresponding Author: Erhabor Osaro, Professor, Department of Haematology, School of Medical Laboratory Science, College of Health Sciences Usmanu Danfodiyo University Sokoto, Nigeria.
Received: February 21, 2022; Published: March 30, 2022




Abstract

Introduction: Malaria in pregnancy is a global public health problem with associated adverse outcome for mum and baby. Nigeria is a hyper endemic area for malaria and it is a major cause of anaemia in pregnancy aggravated by poor socioeconomic status.

Method: This study evaluated the some haematological parameters, ascorbic acid and pantothenic acid level among Plasmodium-parasitized pregnant women of African descent resident in Sokoto, North Western Nigeria. Participants in this study included 90 pregnant women made up of 60 Plasmodium parasitized women and 30 non-parasitized controls. Participants were recruited from Antenatal Clinic of Specialist Hospital Sokoto. We utilized an interviewer-administered questionnaire to collect socio-demographic data from the participants. Ethylene Diamine Tetra Acetic Acid (EDTA) anticoagulated blood were collected and used for malaria parasite testing. Haematological parameters (HCT, HGB, WBC, RBC and platelet count) were determined using an automated haematology analyzer (Genesis, HA6000). Ascorbic acid testing was carried out on serum samples from the participants using a standard chemical method while pantothenic acid levels was assayed using the ID-VIT pantothenic acid ELISA kit. Data collected was analyzed using the Statistical Package for Social Sciences (version 22.0 SPSS). In all statistical analysis, a p-value ≤ 0.05 was considered significant.

Result: We observed a statistically significant decrease in the HCT, HGB RBC and Platelet counts of the parasitized subjects compared to the non-parasitized controls (t = -3.060, -2.979, -3.354 and -7.840, p = 0.003, 0.004, 0.001 and 0.000) respectively. We observed a significant decrease in the ascorbic acid level of parasitized subjects compared with the non-parasitized controls (t = -5.893p = 0.000*). There were no statistically significant differences when the serum pantothenic acid level was compared between parasitized and non-parasitized controls (t = 0.681, p = 0.498). We observed a strong statistically significant correlation between ascorbic acid and platelet count (r = 0.413 and p = 0.00).

Conclusion: Findings of this study has shown that malaria in pregnancy causes decrease in vitamin C and some of the haematological parameters. There is need to monitor the vitamin C and full blood count of malaria parasitized pregnant women. There may be need to provide parasitized pregnant women with vitamin C supplement.

 

Keywords: Maternal Malaria; Blood Disorders; Vitamin Anti-Oxidants

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Citation: Erhabor Osaro., et al. “Evaluation of Serum Ascorbic, Pantothenic Acid Level and Full Blood Count among Plasmodium Parasitized Pregnant Women in Sokoto Specialist Hospital, Sokoto, Nigeria”. EC Paediatrics 11.4 (2022): 36-49.

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