Research Article
Volume 10 Issue 2 - 2021
Congenital Anomalies in Desse Referral Hospital, the Amhara Region, Northeast Ethiopia
Molla Taye*
School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia
*Corresponding Author: Molla Taye, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.
Received: September 26, 2020; Published: January 23, 2021




Abstract

Introduction: Congenital anomalies are defined as structural and functional anomalies that develop during the organogenesis period. Basically, congenital anomalies cause morbidity and mortality. According to the literature, genetic and environmental factors play a major role in the formation of congenital anomalies during the body organs developing period.

Objective: The main objective of this study was to investigate prevalence of congenital anomaly in Desse referral hospital, the Amhara region, Northeast Ethiopia.

Methods: A cross sectional study design was used for this study. The sample size was all children with congenital anomalies during the study period. All children of 0 - 14 years old who visited the study hospital for medical care and treatment were screened for congenital anomalies. Children with confirmed diagnosis of congenital anomalies, and their mothers who volunteered and gave consents to participate in the study on behalf of their children were included in the study irrespective of their age and ethnicity. A structured closed and open-ended questionnaire was designed for the study. Descriptive analysis was done by computing frequency and cross tabulation. Significance level was considered when the p-value is < 0.05. The findings were compared to those of other similar prevalence studies on congenital anomalies in local and some countries of the world. The results were presented in the form of texts and tables.

Results: The overall prevalence of congenital anomalies were 4.4%. Out of the 160 children with congenital anomalies, 58.8% were male. The majority (54.4%) of the children were rural dwellers. Among the anomalies prevalence of neural tube, musculoskeletal system and syndrome disorders were 64.4%, 14.4% and 14.4%, respectively.

Conclusion: In this study, prevalence of congenital anomaly was higher. Therefore, the Amhara regional state health bureau should take public health actions.

Keywords: Congenital Anomalies; Desse Referral Hospital; Neural Tube, Musculoskeletal System

References

  1. Taye M., et al. “Congenital anomalies prevalence in Addis Ababa and the Amhara region, Ethiopia: a descriptive cross-sectional study”. BMC Pediatrics 19 (2019): 234.
  2. Taye M., et al. “Magnitude of Birth Defects in Central and Northwest Ethiopia from 2010-2014: A Descriptive Retrospective Study”. PLoS ONE10 (2016): e0161998.
  3. World Health Organization/US-Center for disease control and prevention/international clearance house on birth defects surveillance and research. birth defects surveillance: a manual for programme managers”. Geneva: World Health Organization (2014).
  4. Shawky RM and Sadik DI. “Congenital malformations prevalent among Egyptian children and associated risk factors”. The Egyptian Journal of Medical Human Genetics 12 (2011): 69-78.
  5. Campana H., et al. “Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina”. Archivos Argentinos de Pediatria5 (2010): 409-417.
  6. Arbour L., et al. “Rates of congenital anomalies and other adverse birth outcomes in an offspring cohort of registered nurses from British Columbia, Canada”. Canadian Public Health Association3 (2010): 230-234.
  7. Manyama M., et al. “An assessment of orofacial clefts in Tanzania”. BMC Oral Health5 (2011): 1-6.
  8. Francine R., et al. “Congenital anomalies: prevalence and risk factors”. Universal Journal of Public Health2 (2014): 58-63.
  9. Kucik JE., et al. “Racial/ethnic variations in the prevalence of selected major birth defects, Metropolitan Atlanta, 1994-2005”. Public Health Reports 127 (2012): 52-61.
  10. Prajapati V., et al. “Study of congenital malformation in neonates born at tertiary care hospital”. National Journal of Community Medicine1 (2015): 30-34.
  11. Sun G., et al. “Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China”. World Journal of Pediatrics 4 (2011): 331-336.
  12. Postoev VA., et al. “Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study”. Reproductive Health3 (2015): 1-8.
  13. Oliveira ClF., et al. “Birth defects in newborns and stillborns: an example of the Brazilian reality”. BMC Research Notes343 (2011): 1-6.
  14. Serra-Juhe C., et al. “Contribution of rare copy number variants to isolated human malformations”. PLoS ONE10 (2012): 1-8.
  15. World Health Organization Regional Office for South-East Asia: Workshop on birth defects surveillance”. Colombo Sri Lanka (2012): 10-13.
  16. Tayebi N., et al. “The prevalence of congenital malformations and its correlation with consanguineous marriages”. Oman Medical Journal 1 (2010): 37-40.
  17. Obu HA., et al. “Congenital malformations among newborns admitted in the neonatal unit of a tertiary hospital in Enugu, Southeast Nigeria- a retrospective study”. BMC Research Notes177 (2012): 1-6.
  18. Zhang X., et al. “Prevalence of birth defects and risk-factor analysis from a population-based survey in inner Mongolia, China”. BMC Pediatrics125 (2012).
  19. Shaw W. “Global Strategies to Reduce the Health Care Burden of Craniofacial Anomalies: Report of WHO Meetings on International Collaborative Research on Craniofacial Anomalies”. Cleft Palate-Craniofacial Journal3 (2004): 238-243.
  20. Primary health care approaches for prevention and control of congenital and genetic disorders. Geneva, Switzerland. WHO (1999).
  21. Global strategies to reduce the health-care burden of craniofacial anomalies. Geneva Switzerland 5-8 November 2000 Park city Utah USA 24-26 May 2001: Human Genetics Programme - 2002, management of noncommunicable diseases. World Health Organization. Geneva, Switzerland; (2000).
  22. Global registry and database on craniofacial anomalies. Eds: WHO publications Geneva Switzerland (2003).
  23. Tessema T and Abuohay M. “Congenital malformations in Gondar Hospital Ethiopia”. The East African Medical Journal 8 (1995): 495-497.
  24. Anyanwu L-JC., et al. “Birth Prevalence of overt congenital anomalies in Kano Metropolis: Overt Congenital Anomalies in the Kano”. Universal Journal of Public Health2 (2015): 89-96.
  25. Mashuda F., et al. “Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania”. BMC Research Notes195 (2014).
  26. Butt F., et al. “Pattern and outcome of congenital anomalies and maternal risk factors association”. Biomedica 29 (2013): 234-239.
  27. Muga R., et al. “Congenital malformation among newborns in Kenya”. African Journal of food Agriculture Nutrition and Development 3 (2009): 815-829.
  28. Bakare TIB., et al. “Epidemiology of external birth defects in neonates in South Western Nigeria”. African Journal of Paediatric Surgery 1 (2009): 28-30.
  29. Sarkar S., et al. “Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India”. Journal of Clinical Neonatology 3 (2013): 131-134.
Citation: Molla Taye. “Congenital Anomalies in Desse Referral Hospital, the Amhara Region, Northeast Ethiopia”. EC Paediatrics 10.2 (2021): 48-56.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


March Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the March issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for April Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the April issue of respective journals. Submissions are accepted on/before March 22, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk