Research Article
Volume 10 Issue 2 - 2021
Congenital Anomalies in Desse Referral Hospital, the Amhara Region, Northeast Ethiopia
Molla Taye*
School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia
*Corresponding Author: Molla Taye, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.
Received: September 26, 2020; Published: January 23, 2021


Introduction: Congenital anomalies are defined as structural and functional anomalies that develop during the organogenesis period. Basically, congenital anomalies cause morbidity and mortality. According to the literature, genetic and environmental factors play a major role in the formation of congenital anomalies during the body organs developing period.

Objective: The main objective of this study was to investigate prevalence of congenital anomaly in Desse referral hospital, the Amhara region, Northeast Ethiopia.

Methods: A cross sectional study design was used for this study. The sample size was all children with congenital anomalies during the study period. All children of 0 - 14 years old who visited the study hospital for medical care and treatment were screened for congenital anomalies. Children with confirmed diagnosis of congenital anomalies, and their mothers who volunteered and gave consents to participate in the study on behalf of their children were included in the study irrespective of their age and ethnicity. A structured closed and open-ended questionnaire was designed for the study. Descriptive analysis was done by computing frequency and cross tabulation. Significance level was considered when the p-value is < 0.05. The findings were compared to those of other similar prevalence studies on congenital anomalies in local and some countries of the world. The results were presented in the form of texts and tables.

Results: The overall prevalence of congenital anomalies were 4.4%. Out of the 160 children with congenital anomalies, 58.8% were male. The majority (54.4%) of the children were rural dwellers. Among the anomalies prevalence of neural tube, musculoskeletal system and syndrome disorders were 64.4%, 14.4% and 14.4%, respectively.

Conclusion: In this study, prevalence of congenital anomaly was higher. Therefore, the Amhara regional state health bureau should take public health actions.

Keywords: Congenital Anomalies; Desse Referral Hospital; Neural Tube, Musculoskeletal System


  1. Taye M., et al. “Congenital anomalies prevalence in Addis Ababa and the Amhara region, Ethiopia: a descriptive cross-sectional study”. BMC Pediatrics 19 (2019): 234.
  2. Taye M., et al. “Magnitude of Birth Defects in Central and Northwest Ethiopia from 2010-2014: A Descriptive Retrospective Study”. PLoS ONE10 (2016): e0161998.
  3. World Health Organization/US-Center for disease control and prevention/international clearance house on birth defects surveillance and research. birth defects surveillance: a manual for programme managers”. Geneva: World Health Organization (2014).
  4. Shawky RM and Sadik DI. “Congenital malformations prevalent among Egyptian children and associated risk factors”. The Egyptian Journal of Medical Human Genetics 12 (2011): 69-78.
  5. Campana H., et al. “Births prevalence of 27 selected congenital anomalies in 7 geographic regions of Argentina”. Archivos Argentinos de Pediatria5 (2010): 409-417.
  6. Arbour L., et al. “Rates of congenital anomalies and other adverse birth outcomes in an offspring cohort of registered nurses from British Columbia, Canada”. Canadian Public Health Association3 (2010): 230-234.
  7. Manyama M., et al. “An assessment of orofacial clefts in Tanzania”. BMC Oral Health5 (2011): 1-6.
  8. Francine R., et al. “Congenital anomalies: prevalence and risk factors”. Universal Journal of Public Health2 (2014): 58-63.
  9. Kucik JE., et al. “Racial/ethnic variations in the prevalence of selected major birth defects, Metropolitan Atlanta, 1994-2005”. Public Health Reports 127 (2012): 52-61.
  10. Prajapati V., et al. “Study of congenital malformation in neonates born at tertiary care hospital”. National Journal of Community Medicine1 (2015): 30-34.
  11. Sun G., et al. “Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China”. World Journal of Pediatrics 4 (2011): 331-336.
  12. Postoev VA., et al. “Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study”. Reproductive Health3 (2015): 1-8.
  13. Oliveira ClF., et al. “Birth defects in newborns and stillborns: an example of the Brazilian reality”. BMC Research Notes343 (2011): 1-6.
  14. Serra-Juhe C., et al. “Contribution of rare copy number variants to isolated human malformations”. PLoS ONE10 (2012): 1-8.
  15. World Health Organization Regional Office for South-East Asia: Workshop on birth defects surveillance”. Colombo Sri Lanka (2012): 10-13.
  16. Tayebi N., et al. “The prevalence of congenital malformations and its correlation with consanguineous marriages”. Oman Medical Journal 1 (2010): 37-40.
  17. Obu HA., et al. “Congenital malformations among newborns admitted in the neonatal unit of a tertiary hospital in Enugu, Southeast Nigeria- a retrospective study”. BMC Research Notes177 (2012): 1-6.
  18. Zhang X., et al. “Prevalence of birth defects and risk-factor analysis from a population-based survey in inner Mongolia, China”. BMC Pediatrics125 (2012).
  19. Shaw W. “Global Strategies to Reduce the Health Care Burden of Craniofacial Anomalies: Report of WHO Meetings on International Collaborative Research on Craniofacial Anomalies”. Cleft Palate-Craniofacial Journal3 (2004): 238-243.
  20. Primary health care approaches for prevention and control of congenital and genetic disorders. Geneva, Switzerland. WHO (1999).
  21. Global strategies to reduce the health-care burden of craniofacial anomalies. Geneva Switzerland 5-8 November 2000 Park city Utah USA 24-26 May 2001: Human Genetics Programme - 2002, management of noncommunicable diseases. World Health Organization. Geneva, Switzerland; (2000).
  22. Global registry and database on craniofacial anomalies. Eds: WHO publications Geneva Switzerland (2003).
  23. Tessema T and Abuohay M. “Congenital malformations in Gondar Hospital Ethiopia”. The East African Medical Journal 8 (1995): 495-497.
  24. Anyanwu L-JC., et al. “Birth Prevalence of overt congenital anomalies in Kano Metropolis: Overt Congenital Anomalies in the Kano”. Universal Journal of Public Health2 (2015): 89-96.
  25. Mashuda F., et al. “Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania”. BMC Research Notes195 (2014).
  26. Butt F., et al. “Pattern and outcome of congenital anomalies and maternal risk factors association”. Biomedica 29 (2013): 234-239.
  27. Muga R., et al. “Congenital malformation among newborns in Kenya”. African Journal of food Agriculture Nutrition and Development 3 (2009): 815-829.
  28. Bakare TIB., et al. “Epidemiology of external birth defects in neonates in South Western Nigeria”. African Journal of Paediatric Surgery 1 (2009): 28-30.
  29. Sarkar S., et al. “Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India”. Journal of Clinical Neonatology 3 (2013): 131-134.
Citation: Molla Taye. “Congenital Anomalies in Desse Referral Hospital, the Amhara Region, Northeast Ethiopia”. EC Paediatrics 10.2 (2021): 48-56.

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