Review Article
Volume 10 Issue 2 - 2021
Does Silver Diamine Fluoride Effective in Caries Prevention in Children?
Karimi M*
Department of Pediatrics Dentistry, Sepideh Dental Clinic, Iran
*Corresponding Author: Karimi M, Department of Pediatrics Dentistry, Sepideh Dental Clinic, Iran.
Received: October 17, 2020; Published: January 21, 2021


This article has focused on the evaluation of the scientific evidence of the effectiveness of silver diamine fluoride (SDF) in caries prevention and caries arresting in both the primary and the permanent teeth in children. The candidates for SDF treatment are selected based on some criteria through a complete dental examination.

Keywords: Silver Diamine Fluoride; Caries Prevention; Criteria; Dental Examination; Caries Arresting; Primary and Permanent Teeth; Treatment


  1. Zhao IS., et al. “Mechanisms of silver diamine fluoride on arresting caries: a literature review”. International Dental Journal2 (2018): 67-76.
  2. Rosenblatt A., et al. “Silver diamine fluoride: a caries "silver-fluoride bullet”. Journal of Dental Research2 (2009): 116-125.
  3. Oliveira BH., et al. “The Effect of Silver Diamine Fluoride in Preventing Caries in the Primary Dentition: A Systematic Review and Meta-Analysis”. Caries Research1 (2019): 24-32.
  4. Crystal YO and Niederman R. “Silver Diamine Fluoride Treatment Considerations in Children's Caries Management”. Pediatric Dentistry7 (2016): 466-471.
  5. Horst Jeremy A., et al. “UCSF Protocol for Caries Arrest Using Silver Diamine Fluoride: Rationale, Indications, and Consent”. Journal of the California Dental Association1 (2016): 16-28.
  6. Shirley ST. “Silver diamine fluoride for the prevention and arresting of dental caries or hypersensitivity: a review of clinical effectiveness, cost-effectiveness and guidelines. Ottawa (ON): CADTH (2017).
  7. Mei ML., et al. “Clinical use of silver diamine fluoride in dental treatment”. Compendium of Continuing Education in Dentistry 2 (2016): 93-98.
  8. Fung MHT., et al. “Arresting Dentine Caries with Different Concentration and Periodicity of Silver Diamine Fluoride”. JDR Clinical and Translational Research2 (2016): 143-152.
  9. Llodra JC., et al. “Efficacy of silver diamine fluoride for caries reduction in primary teeth and first permanent molars of schoolchildren: 36-month clinical trial”. Journal of Dental Research 8 (2005): 721-724.
  10. Subbiah GK and Gopinathan NM. "Is Silver Diamine Fluoride Effective in Preventing and Arresting Caries in Elderly Adults? A Systematic Review”. Journal of International Society of Preventive and Community Dentistry3 (2018): 191-199.
  11. Chu CH., et al. “Effectiveness of Silver Diamine Fluoride and Sodium Fluoride Varnish in Arresting Dentin Caries in Chinese Pre-school Children”. Journal of Dental Research 11 (2002): 767-770.
  12. Selvig KA. “Ultra structural changes in human dentine exposed to a weak acid”. Archives of Oral Biology 7 (1968): 719-734.
  13. Yamaga R., et al. “Diammine silver fluoride and its clinical application”. The Journal of Osaka University Dental School 12 (1972): 1-20.
  14. Castillo J., et al. “The short term effects of diamine silver fluoride on tooth sensitivity: a randomized controlled trial”. Journal of Dental Research 2 (2011): 203-208.
  15. Taylor BJ. “Switzerland diamine fluoride”. Membership Matters 19 (2013): 3.
  16. Bernadette Alvear Fa., et al. “Caries arrest with silver diamine fluoride”. Decision in Dentistry (2016): 48-51.
  17. American Academy of Pediatric Dentistry, Use of Silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs”. Pediatrics Dentistry6 (2017): 146-155.
  18. Rebecca L Slayton., et al. “Evidence-based clinical practice guideline on nonrestorative treatments for carious lesions, A report from the American Dental Association”. JADA10 (2018): 837-849.
  19. Chu Chun-Hung., et al. “The effectiveness of the biannual application of silver nitrate solution followed by sodium fluoride varnish in arresting early childhood caries in preschool children: study protocol for a randomized controlled trial”. Trials 16 (2015): 426.
  20. Santos Junior VED., et al. “An approach to arrest and prevent caries in children: Silver Diamine Fluoride”. RFO UPF2 (2012): 228-233.
  21. Marina de Lourdes., et al. “Preventive Methods Applied to the Occlusal Surface of Primary Teeth: A Randomized Clinical Study”. Pesquisa Brasileira em Odontopediatria e Clinica Integrada1 (2018): e3675.
  22. Contreras V., et al. “Effectiveness of silver diamine fluoride in caries prevention and arrest: a systematic literature review”. General Dentistry 3 (2017): 22-29.
  23. Dos Santos VE., et al. “Paradigm shift in the effective treatment of caries in schoolchildren at risk”. International Dental Journal 1 (2012): 47-51.
  24. Monse B., et al. “Caries-preventive efficacy of silver diamine fluoride (SDF) and ART sealants in a school-based daily fluoride tooth brushing program in the Philippines”. BMC Oral Health 12 (2012): 52.
  25. Moher D., et al. “Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement”. PLOS Medicine 7 (2009): e1000097.
  26. Gao SS., et al. “Clinical trials of silver diamine fluoride in arresting caries among children: a systematic review”. The JDR Clinical and Translational Research 3 (2016): 201-210.
  27. Shah S., et al. “Silver diamine fluoride: a review and current applications”. Journal of Advanced Oral Research1 (2014): 25-35.
Citation: Karimi M. “Does Silver Diamine Fluoride Effective in Caries Prevention in Children?”. EC Paediatrics 10.2 (2021): 34-38.

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