Case Report
Volume 10 Issue 2 - 2021
Toxic Megacolon: Presentation of A Case and Review of the Literature
Jimena Cárdenas Morocho1, Lizeth Criollo Yaguana1 and Iveth Vargas Guilcaso2*
1Resident Physician of Pediatrics and Neonatology, Macas General Hospital, Ecuador
1Pediatrician, General Hospital Macas, Ecuador
*Corresponding Author: Iveth Vargas Guilcaso, Pediatrician, General Hospital Macas, Ecuador.
Received: November 10, 2020; Published: January 19, 2021


Toxic megacolon is a serious infrequent condition with high hospital mortality, it is non obstructive colonic distention greater than 6cm, associated with acute colitis and systemic symptoms. The manifestation include: vomiting, diarrhea, rectal bleeding, tenesmus, abdominal pain, fever, even signs of systemic toxicity.

The pathophysiological mechanisms involved include elevated concentrations of nitric oxide and inflammatory mediators resulting from initial aggression to the colon. Due to its high morbidity and mortality, early diagnosis and treatment are essential.

Follow up with imaging studies is decisive to detect complications in a timely manner and to evaluate the inflammatory process. Treatment includes: water resuscitation, metabolic correction, antibiotics and effective surgical management to avoid as much as possible complications that worsen the prognosis of patients.

Keywords: Toxic Megacolon; Colitis; Systemic Toxicity


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Citation: Iveth Vargas Guilcaso., et al. “Toxic Megacolon: Presentation of A Case and Review of the Literature”. EC Paediatrics 10.2 (2021): 17-21.

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