Review Article
Volume 10 Issue 1 - 2021
Treating Epilepsy in Patients with Rett Syndrome - Options and Challenges
Natalija Krajnc*
Department of Pediatrics, General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia
*Corresponding Author: Natalija Krajnc, Department of Pediatrics, General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
Received: October 27, 2020; Published: December 31, 2020


Rett syndrome is a frequent neurodevelopmental disorder that manifests in infancy with the regression of previously acquired motor and verbal skills. The specific brain areas are affected with the arrest of the neuronal growth and their connectivity.
The majority of patients has epilepsy in the early clinical stages of the disease which usually becomes less active in the adolescent age. Besides epilepsy other paroxysmal events are present in majority of Rett patients and may mimick epileptic seizures. Antiepileptic drug treatment is successful and the prevalence of drug resistant epilepsy is about equal to patients with other newly-diagnosed epilepsy. Valproate, carbamazepine and lamotrigine were the most frequently used and reported effective. The epilepsy usually becomes less active in the adolescence and the common guidelines for withdrawal of antiepileptic drugs could be implemented also in Rett patients.

Keywords: Rett Syndrome; Epilepsy; Treatment


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Citation: Natalija Krajnc. “Treating Epilepsy in Patients with Rett Syndrome - Options and Challenges”. EC Paediatrics 10.1 (2021): 72-79.

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