Case Report
Volume 9 Issue 8 - 2020
Case Report: Fatal Vaccine Strain Measles Infection in a Child
Roberto Calzada-Lang1, Adriana Yock-Corrales2*, Mónica Nuñez3 and Marcela Hernández-de Meserville1
1Infection Prevention and Control Disease Department, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, CCSS, San José, Costa Rica
2Emergency Department, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, CCSS, San José, Costa Rica
3Pathology Department, Hospital Nacional de Niños Dr. Carlos Sáenz Herrera”, CCSS, San José, Costa Rica
*Corresponding Author: Adriana Yock-Corrales, Emergency Department, Hospital Nacional de Niños “Dr. Carlos Sáenz Herrera”, CCSS, San José, Costa Rica.
Received: May 27, 2020; Published: July 15, 2020


Measles outbreaks has become a popular topic due to anti-vaccination movements. Severe side effects after Mumps Measles Rubella (MMR) vaccination is a rare event. This is a case report of a 15-month-old patient who presented to the emergency department (ED) with a thirteen-day history of fever, maculopapular rash with hemorrhagic lesions and purpuric crusts; with previous MMR vaccination 4-days before symptoms. After he was stabilized in the ED, he was admitted in the ICU where he died due to severe septic shock and multiorgan failure. Vaccine strain measles infection was confirmed by Control of Disease Center (CDC).

Keywords: Measles; Vaccine Strain; Pediatrics


  1. The Word Health Organization. “Measles vaccines: Measles vaccines: WHO position paper, April 2017 – Recommendations”. Elsevier 37 (2017): 219-222. 
  2. Goodson JL and Seward JF. “Measles 50 Years After Use of Measles Vaccine”. Elsevier 29 (2015): 725-743. 
  3. Griffin DE. “Measles virus and the nervous system”. The Handbook of Clinical Neurology 123 (2014): 577-590.
  4. Epidemiology and Prevention of Vaccine-Preventable Diseases (The Pink Book), 12th edition, Atkinson W, Wolfe C, Hamborsky J (Editions), The Public Health Foundation, Washington, DC (2011).
  5. The Word Health Organization. Immunization, Vaccines and Biologicals: Measles (2018). 
  6. The MMR-161 Study Group. “Immunogenicity and safety of measles-mumps-rubella vaccine at two different potency levels administered to healthy children aged 12-15months: A phase III, randomized, non-inferiority trial”. Vaccine 36 (2018): 5781-5788. 
  7. Klein N., et al. “Safety of Measles-Containing Vaccines in 1-Year-Old Children”. Pediatrics 135 (2015): 2010-2035.
  8. Cochi SL. “Pivoting from polio eradication to measles and rubella elimination: a transition that makes sense both for children and immunization program improvement”. The Pan African Medical Journal 21.3 (2017): 10. 
  9. Abedi GR., et al. “Adverse events following a third dose of measles, mumps, and rubella vaccine in a mumps outbreak”. Vaccine 30 (2012): 7052-7058.
  10. Cheng-qiang Jin., et al. “Acute immune thrombocytopenic purpura as adverse reaction to oral polio vaccine (OPV)”. Human Vaccines and Immunotherapeutics 9 (2013): 1739-1740. 
  11. Erlewyn M., et al. “Anaphylaxis as an adverse event following immunization”. Journal of Clinical Pathology 60 (2017): 737-739.
  12. Lorry G Rubin., et al. “IDSA clinical practice guideline for vaccination of the immunocompromised host” 58 (2013): e44-e100. 
  13. Poon TP., et al. “Subacute measles encephalitis with AIDS diagnosed by fine needle aspiration biopsy. A case reports”. Acta Cytological 42 (1998): 729-733. 
Citation: Adriana Yock-Corrales., et al. “Case Report: Fatal Vaccine Strain Measles Infection in a Child”. EC Paediatrics 9.8 (2020): 93-98.

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