Review Article
Volume 9 Issue 8 - 2020
Herpes Simplex Virus Infections In Neonate
Baraah Badee Damanhouri*, Rawan Nasser Al-Mehmadi, Ruba Saud Alsharif, Fatema Ahmed, Waad Hassan Alotibi, Lina Hassan Bugis, Rzan Waleed Melibari, Haneen Ahmed Abba, Eatimad Ahmad Alalawi and Rawan Abdulkhaliq Wazuddin
Maternity and Children Hospital in Makkah, Mecca, Saudi Arabia
*Corresponding Author: Baraah Badee Damanhouri, Maternity and Children Hospital in Makkah, Mecca, Saudi Arabia.
Received: June 24, 2020; Published: July 11, 2020


Introduction: Although neonatal herpes infection is relatively uncommon, neonatal HSV causes serious morbidity and mortality, and survivors may need to live with permanent sequelae.

Aim of Work: In this review, we will discuss the most recent evidence regarding neonatal herpes simplex virus, methods of diagnosis, and management.

Methodology: We did a thorough search for most recent available evidence regarding the diagnosis and management of herpes simplex virus (HSV) in neonate.

Conclusion: The disease is classified clinically to three main types: SEM, CNS herpes simplex virus; disseminated HSV infection. Physicians’ high index of suspicion is essential to consider neonatal HSV. Polymerase chain reaction (PCR) is more sensitive than viral culture for CSF samples. However, false negative results could be seen and should not exclude the diagnosis in case of high suspicion. The Adequate Neonatal HSV management consists of support measures and antiviral therapy. Supporting steps are especially important for CNS involvement and for disseminated HSV. Acyclovir have led to sharp decrease in the mortality rate and considered the drug of choice. Ganciclovir IV was suggested to be the first-line alternative to acyclovir.

Keywords: Neonatal Herpes Simplex Virus; Neonatal HSV; Complication of HSV; Pregnant with HSV; Simplex with CNS Involvement.


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Citation: Baraah Badee Damanhouri., et al. “Herpes Simplex Virus Infections In Neonate”. EC Paediatrics 9.8 (2020): 64-72.

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