Case Report
Volume 9 Issue 8 - 2020
Septic Arthritis due to Neisseria meningitidis Serogroup W in Toddlers
Laura Corominas1*, I Manent2, A Peiro1 and E Velasco3
1Pediatric Orthopedic Surgeon, Hospital Sant Joan de Deu, Barcelona, Spain
2Pediatric Orthopedic Resident, Fundació Hospital Esperit Sant, Spain
3Pediatric Medical Doctor, Hospital Sant Joan de Deu, Barcelona, Spain
*Corresponding Author: Laura Corominas, Pediatric Orthopedic Surgeon, Hospital Sant Joan de Deu, Barcelona, Spain.
Received: April 13, 2020; Published: July 29, 2020




Abstract

Introduction: Since 2009, there has been a serious increase in the number of meningococcal infections in Europe caused by the serotype W meningococcus (MenW:cc11). Invasive meningococcal disease is typically known to cause severe sepsis or meningitis with high overall mortality rates of 10% despite adequate antimicrobial treatment. Focal infections such as arthritis incidentally occur as a complication of systemic disease.

Case Report: We describe a rare case of primary meningococcal W135 arthritis in a 2-year-old patient.

Results: Arthrocentesis of the right Ankle while patient was under anesthesia, yielded grossly purulent fluid, so we made arthrotomy and drainage. The culture from synovial fluid revealed N. meningitidis. The status of the patient improved after surgical drainage and intravenous antibiotic therapy. She recovered completely after 1 month.

Discussion: Atypical clinical presentation is associated with higher case fatality rates and can lead to misdiagnoses. An unusual presentation of invasive meningococcal infection and the early identification of the bacteria, combined with the correct treatment, prevent the complications and even death.

Keywords: Serogroup W; Primary Meningococcal Septic Arthritis; Toddler; Atypical Presentation

References

  1. Kappan SL., et al. “Multicenter surveillance of invasive meningococcal infections in children”. Pediatrics 118 (2006): e979-e984.
  2. Kelly D and Pollard AJ. “W135 in Africa: origins, problems and perspectives”. Travel Medicine and Infectious Disease 1 (2003): 19-28.
  3. Stinson C., et al. “Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci”. Epidemiology and Infection 148 (2020): e12.
  4. Giamarellos-Bourboulis EJ., et al. “Primary meningococcal arthritis: case report and clinical review”. Clinical and Experimental Rheumatology (2002): 553-554.
  5. Fidder AR., et al. “Child with serogroup W135 primary meningococcal septic arthritis”. BMJ Case Reports 12 (2019): e229510.
  6. Knol Mj., et al. “Temporal associations between national outbreaks of meningococcal serogroup W and C disease in the Netherlands and England: an observational cohort study”. Lancet Public Health 2 (2017): e473.e482.
  7. Mori N., et al. “ Meningococcal meningitis with neurological complications and meningoccemia due to serogroup W sequence type 11 complex”. Journal of infection and Chemotherapy 24 (2018): 398-400.
  8. Harrison LH., et al. “Global Epidemiology of meningococcal disease”. Vaccine 27.2 (2009): B51-B63.
  9. Christensen H., et al. “Meningococcal carriage by age: a systematic review and meta-analysis”. The Lancet Infectious Diseases 10 (2010): 853-861.
  10. Brawley RI., et al. “Acute Septic arthritis caused by Neisseria Meningitidis serogroup W -135”. Southern Medical Journal 73 (1980): 395-396.
  11. Moll-Manzur C., et al. “Artritis septica de rodilla por Neisseria Meningitidis serogroup W-135: primer caso reportado en un adulto”. Journal Medical and Clinical 147 (2016): 225-226.
  12. Gee C., et al. “Primary Meningococcal septica arthritis of the ankle joint: a case report”. The Journal of Foot and Ankle Surgery 53 (2014): 216-218.
  13. Ricci S., et al. “Is primary meningococcal arthritis in children more frequent than we expect? Two pediatric case reports revealed by molecular test”. BMC Infectious Diseases 18.18 (2018): 703.
  14. Bilavasky E., et al. “Primary meningococcal arthritis in a child: case report and literature review”. Scandinavian Journal of Infectious Diseases 38 (2006): 396-399.
  15. McMullan B. “An infant with meningococcal arthritis of the hip”. Journal of Paediatrics and Child Health 45 (2009): 762-763.
  16. Apfalter P., et al. “Neisseria Meningitidis serogroup W-135 primary monoarthritis of the hip in an immunocompetent child”. European Journal of Clinical Microbiology and Infectious Diseases 19 (2000): 475-476.
Citation: Laura Corominasz., et al. “Septic Arthritis due to Neisseria meningitidis Serogroup W in Toddlers”. EC Paediatrics 9.8 (2020): 01-05.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


July Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the July issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before July 19, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.