Research Article
Volume 9 Issue 6 - 2020
Epidemiological Aspect of Febrile Convulsive Seizures in Infants and Children in Libreville, Gabon
Minko JI1,2, Lembet Mikolo AM1,2, Essola L1,4, Louembet FC1,2, Minto’o S1,2*, Nganga Singatady Zang LM5 and Ategbo SJ2,3
1Centre Hospitalier Universitaire de Libreville-BP, Libreville, Gabon
2Département de Pédiatrie. Faculté de Médecine et des Sciences de la Santé-BP, Owendo, Gabon
3Centre Hospitalier Universitaire Mère-Enfant- Fondation Jeanne Ebori-Libreville, Gabon
4Service des Urgences Pédiatriques du Centre Hospitalier Universitaire de Libreville, Libreville, Gabon
5Ministère de la Santé, Libreville, Gabon
*Corresponding Author: Minto’o S, Centre Hospitalier Universitaire de Libreville-BP, Libreville, Gabon.
Received: March 30, 2020; Published: May 15, 2020


A prospective, observational and transverse study, carried out in pediatric emergency units and in-patients at Centre Hospitalier de Libreville and Hôpital Régional de l’Estuaire de Mélen, from May to September 2011, included 99 infants and children aged between 6 months and 15 years admitted for convulsive seizures in a febrile context. These seizures represented 3.0% of paediatric hospitalisations in Libreville.

The mean age was 42.5 ± 31.2 months, with extremes of 6 and 132 months. Sex ratio was 1.2. Most children were under 5 years old. Their parents were mostly High school educated, and without income-generating activities. Birth took place in healthcare centres (97.0%) through vaginal route (97.0%). Histories of convulsions with fever were reported in 25.2% of patients. Simple seizure was the most frequent (64.2%) with a predominance of generalized tonic-clonic seizures. A state of convulsive failure was noted in 10.5% of patients. Malaria was the main cause in 50.5% of patients, including 5 cases of severe malaria, followed by febrile convulsions in 36.4% and purulent meningitis in 17.1% cases. Hypocalcaemia was found in 26.1% of patients. The average hospital stay was 5±2 days. The disease evolution was favourable for 91.9% of children and death was recorded for 4.1%.

Febrile convulsive seizures are a leading cause of hospital admissions in Libreville and the prognosis depends on etiology. In order to improve management of such patients and to avoid sequalae, further bacteriological and virological investigations are needed, as well as ruling out severe malaria or meningitis, reinforcing anti-malaria prevention methods and raising families' awareness about meningitis vaccine.

Keywords: Seizure; Convulsion; Febrile; Child; Prognostic


  1. Sadleir LG and Scheffer IE. “Febrile seizures”. British Medical Journal 334 (2007): 307-311.
  2. Mendoca de Siquera LF. “Febrile seizures: Update on diagnosis and management”. Revista da Associação Médica Brasileira 56 (2010): 489-492.
  3. Carmant L. “Les convulsions fébriles chez l’enfant”. Le Clinicien 17 (2002): 81-89.
  4. Pedespan JM. “Convulsions febriles”. Mt Pediatrie 9 (2006): 275-278.
  5. Pedespan L. “Convulsions hyperthermiques”. Archives de Pédiatrie 14 (2007): 394-398.
  6. Diawara FN., et al. “Aspects épidémiologiques des convulsions fébriles du nourrisson et de l’enfant. Dans le service de pédiatrie de l’hôpital Gabriel Touré (Bamako)”. Médicale d'Afrique Noire 38 (1991): 124-127.
  7. Nguefack S., et al. “Aspects cliniques, étiologiques et thérapeutiques des convulsions fébriles. A propos de 325 cas à Yaoundé”. Archives de Pédiatrie 17 (2010): 480-485.
  8. Berkley JA., et al. “Cerebral malaria versus bacterial meningitisis in children with impaired consciousness”. QJM: An International Journal of Medicine 92 (1999): 151.
  9. Senga P., et al. “Profil des convulsions du Nourrisson et du jeune enfant à Brazzaville (Congo)”. Annales de Pédiatrie 5 (1985) :477-480.
  10. Dembélé A., et al. “Étiologies des Convulsions Fébriles Chez l’Enfant de Un à 59 Mois dans le Service des Urgences Pédiatriques du CHU Gabriel Toure”. Health Sciences and Diseases3 (2019): 1-4.
  11. Hirtz DG and Nelson KB. “The natural history of febrile seizures”. Annual Review of Medicine 34 (1983): 453-471.
  12. Jensen AT and Sanchez RM. “Why does the developing brain demonstrate heightened susceptibility to febrile and other provoked seizures?” In: Febrile seizures. TZ Baran and S Shinnar. Academic Press (2002): 153-168.
  13. Graveleau D and Salbreux R. “Etude statistique de 667 cas de convulsions fébriles”. Journées Parisiennes de Pédiatrie (1972): 246-256.
  14. Johnston MV and Hagberg H. “Sex and the pathogenesis of cerebral palsy”. Developmental Medicine and Child Neurology 49 (2007): 74-78.
  15. Sall MG., et al. “Les convulsions hyperpyrétiques au CHU de Dakar”. Médicale d'Afrique Noire 39 (1992): 119-121.
  16. , et al. “Risk factors for febrile convulsions”. Epidemiology 13 (2002): 282-287.
  17. Chiabi A., et al. “The clinical spectrum of severe malaia in children in the east provincial hospital of Bertoua, Cameroun”. Bulletin de la Société de Pathologie Exotique 97 (2004): 239-243.
  18. Kariuki SM., et al. “Acute seizures attributable to falciparum malaria in an endemic area in the Kenyan coast”. Brain 134 (2011): 1519-1528.
  19. Mohammagreza SO., et al. “Febrile seizures in North Iranian children–epidemiology and clinical features”. The Journal of Pediatric Neurology 6 (2008): 39-42.
  20. Chevrie JJ. “Les convulsions fébriles”. La Revue du Praticien57 (1981): 4105-4115.
  21. Joshi BR., et al. “Children with first episode of fever with seizure: is lumbar puncture necessary?” Journal of Nepal Medical Association 47 (2008): 109-112.
  22. Sahin M., et al. “Outcome of severe refractory status epilepticus in children”. Epilepsia 42 (2001): 1461-1467.
  23. Subcommittee on febrile seizures. “Neurodiagnostic evaluation of the child with a simple febrile seizure”. Pediatrics 27 (2011): 389-394.
  24. Anga G., et al. “The aetiology, clinical presentations and outcome of febrile encephalopathy in children in Papua New Guinea”. Annals of Tropical Paediatrics 30 (2010): 109-118.
  25. Bronzan RN., et al. “Bacteremia im malawian children with severe malaria : prevalence, etiology, HIV coinfection, and outcome”. The Journal of Infectious Diseases 195 (2007): 895-904.
Citation: Minko JI., et al. “Epidemiological Aspect of Febrile Convulsive Seizures in Infants and Children in Libreville, Gabon”. EC Paediatrics 9.6 (2020): 33-39.

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