Abstract

Background: A newly emerging Corona virus disease is necessary to provide international cooperation to regulate this virus. Extended IRS promised to induce immunological dysfunction with qualitative and quantitative. This disease led to age-related disabilities, but only a small proportion of the persons concerned seek medical attention. To concur the microbial disease, an establishment of vaccine is conventional way for prevention. However, virus diseases are different from microbial one, so the development of vaccine for virus diseases may different from bacterial one. 

Purpose: This report suggested that the establish a better virus vaccine innovates from classic vaccine preparation

Pathology of Viral Disease: Therefore, the viruses are absolutely dependent system for the production of their own species, they hide out in the host cell, such as liver cell by liver virus. Immunological attack of IgG antibodies to infected liver cell, induced hepatitis in the host. In other words, there was no pathogenic anomaly just seclusion by liver virus in liver cell.

Discussion Points for the Development of the Vires Vaccine: A High titer of IgG antibodies may damage the virus-infected host cell. Only secretory IgA with secretory piece in the mucus membrane is effective to prevent virus infection. Immunoglobulin classes are absolutely important for the prevention of viral infections as the first line of defense.

Conclusion: 

1. Antibodies against the virus limited to prevent syndrome.
2. It depend on the immunoglobulin (Ig) class.
3. Repeated antigen stimulation induce secondary response that mounted by IgG antibodies.
4. Hemopoietic herbal decoction may play an adjuvant for induce viral vaccine.
5. Serum IgG attacks virus together with host cell that share the room in the host.
6. The immunoglobulin class A, IgA, with secretory piece, is the most important for the development of the newly developing viral vaccine.

Keywords: Viral Disease; Vaccine; COVID-19; Oral Adjuvant; Immunoglobulin Class; IgA; IgM; IgG; Secretory IgA

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