Research Article
Volume 9 Issue 4 - 2020
Aromatherapy of Humulus lupulus Extract for the Management of Nocturnal Enuresis: A Pilot Study in Indian Children
Vikas Gorad1*, Satish Shahane2 and Sagar Mhatre3
1Om Sai Clinic, Nerul, Navi Mumbai, India
2Saanvi Childrens Hospital, Kharghar, Navi Mumbai, India
3Mhatre Clinic, Prabhadevi, Mumbai, India
*Corresponding Author: Vikas Gorad, Om Sai Clinic, Nerul, Navi Mumbai, India.
Received: March 02, 2020; Published: March 16, 2020


Background/Aim: The present study was a pioneer effort to evaluate the efficacy and safety of hops flower (Sinorina Ambientador [Humulus lupulus]) extract aromatherapy in the treatment of nocturnal enuresis (NE) in children.

Methods: Fifty children aged 5-10 years with NE were randomized to receive test intervention: hops flower extract aromatherapy (n = 26) or placebo (almond oil) (n = 24) every night for 60 consecutive days. The primary efficacy assessment was change in NE grading in patients at the end of the study compared to baseline and between two study groups at the end of the study along with global assessment of efficacy by both investigator and patient. The secondary objective was safety and global assessment of tolerability at the end of the study by both investigator and the patient. 

Results: A total of 91.7% children were reduced to grade 0 NE (completely dry) at the end of the study (p = 0.0005) and remained dry even after 15 days of withdrawal from test intervention (p = 0.0005). As per both the investigator’s and the patient’s assessment of efficacy in test group, very good improvement (Grade 1) was observed in 91.7% patients. No adverse events or deaths were observed in the study and the test intervention was well tolerated by all the participating patients. For the test group, both the investigator’s and the patient’s assessment of tolerability was excellent (Grade 1) for all patients. 

Conclusion: The results revealed aromatherapy with hops flower extract to be a safe, effective, and a viable treatment for NE in children.

Keywords: Pediatrics; Sinorina Ambientador; Nocturnal Enuresis; Efficacy; Tolerability


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Citation: Vikas Gorad., et al. “Aromatherapy of Humulus lupulus Extract for the Management of Nocturnal Enuresis: A Pilot Study in Indian Children”. EC Paediatrics 9.4 (2020): 65-72.

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