Research Article
Volume 9 Issue 4 - 2020
Endogenous Cardiotonic Steroids Levels and their Significance in Children with Chronic Kidney Disease
Ievgeniia Burlaka*
Department of Pediatrics №4, O.O. Bogomolets National Medical University, Kyiv, Ukraine
*Corresponding Author: Ievgeniia Burlaka, Department of Pediatrics №4, O.O. Bogomolets National Medical University, Kyiv, Ukraine.
Received: February 28, 2020; Published: March 12, 2020




Abstract

Previous reports demonstrated that digitalis-like cardiotonic steroids (CTS) may contribute to the pathogenesis of end-stage renal disease and its complications. The role of CTS in nature of CKD in pediatric patients is not fully studied. The goal of the present study was to define the levels of CTS in pediatric patients with chronic kidney disease (CKD). In 22 patients with CKD plasma marinobufagenin (MBG) but not endogenous ouabain (EO) was increased as compared to that in 17 healthy individuals. Thus, we speculate that in chronic renal failure elevated levels of bufadienolide CTS MBG may cause the Na/K-ATPase inhibition and may represent a potential target for therapy.

Keywords: Children; Chronic Kidney Disease; Hemodialysis; Marinobufagenin; Ouabain; Na/K-ATPase

References

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Citation: Ievgeniia Burlaka. “Endogenous Cardiotonic Steroids Levels and their Significance in Children with Chronic Kidney Disease”. EC Paediatrics 9.4 (2020): 39-43.

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