Review Article
Volume 9 Issue 3 - 2020
Synbiotics in Control of Pertussis Infection
Stojkovic Andjelka*
Department of Pediatrics Faculty of Medical Sciences, University of Kragujevac, Serbia
*Corresponding Author: Stojkovic Andjelka, Professor, Department of Pediatrics Faculty of Medical Sciences, University of Kragujevac, Serbia.
Received: February 12, 2020; Published: March 12, 2020


The efficiently and effectively treatment of respiratory infection with Bordetella pertussis (BPer) depends on the cellular glucose metabolism (CGM) at the level of the respiratory epithelium and on the activity of the insulin-secreting pancreatic beta cells, which means that the "elective" drug/preparation must have the potential to control CGM. Until now, treatment of respiratory infection with BPer has been partially successful if treated with macrolide at the beginning of the infection but the subsequent course of treatment is symptomatic and insufficiently efficient and effective. The potential of individual probiotic bacteria and synbiotics in controlling CGM, enhancing the host immune response, local immunomodulation at the level of the respiratory epithelium and controlling opportunistic respiratory infection should be considered and clinically evaluated. Synbiotic stimulates enhanced secretion of immunoglobulins A and G which act by neutralizing the pertussis toxin and prevent infection of the epithelial cell and contribute to protection against BPer infection..

Keywords: Pertussis; Child; Probiotics; Treatment


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Citation: Stojkovic Andjelka. “Synbiotics in Control of Pertussis Infection”. EC Paediatrics 9.4 (2020): 28-33.

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