Research Article
Volume 9 Issue 4 - 2020
Metabolic Screening: Experience in Second Level Attention Hospital
Alejandra Itzel Contreras Rivas1* and Gaston Eduardo Estudillo Jimenez2
1Pediatric-Neonatology, Neonatal Intensive Therapy Unit, Maternal and Infant Hospital “Miguel Hidalgo Y Costilla”, Mexico
2Gynecology-Obstetric, Maternal-Fetal Medicine and Fetal Surgery Fellow, Maternal Health Program Manager, Mexico
*Corresponding Author: Alejandra Itzel Contreras Rivas, Pediatric-Neonatology, Neonatal Intensive Therapy Unit, Maternal and Infant Hospital “Miguel Hidalgo Y Costilla”, Mexico.
Received: February 04, 2020; Published: February 26, 2020


The neonatal sieve is a very valuable tool of preventive medicine, through the analysis of various substances in blood drops collected on specific filter paper, currently, the Ministry of Health carries out the neonatal sieve for the detection of six diseases: hypothyroidism congenital, congenital adrenal hyperplasia, phenylketonuria, galactosemia, cystic fibrosis and glucose 6-phosphate dehydrogenase deficiency. The following article was carried out with the purpose of knowing the statistics of confirmed cases through the conduct of metabolic screening.

Keywords: Metabolic Screening; Newborn; Hypothyroidism Congenital; Congenital Adrenal Hyperplasia; Phenylketonuria; Galactosemia; Cystic Fibrosis and Glucose 6-Phosphate Dehydrogenase Deficiency


  1. Tamiz Neonatal Detección, Diagnóstico, Tratamiento y Seguimiento de los Errores Innatos del Metabolismo.
  2. Erika Paola García-Flores., et al. “Avances y logros del programa de tamiz metabólico neonatal (2012-2018)”. Acta Pediátrica de México 39.1 (2018): 57S-65S.
  3. NOM-166-SSA-1997.
  4. A Practical Guide to Newborn Bloodspot Screening, In Ireland. 7th Edition (2018).
  5. Newborn Screening Manual: A guide for newborn care providers, edition 2.1 (2018).
  6. Martina Cornel., et al. “Newborn screening in Europe. Expert Opinion document”.
  7. Maria Knapkova., et al. “Reliability of Neonatal Screening Results”. International Journal of Neonatal Screening 4.3 (2018): 28.
  8. Gema Matilde Calderón López and Francisco Jiménez Parrilla. “Screening neonatal”. Protocolos Diagnóstico Terapéuticos de la AEP: Neonatología.
  9. Bradford L Therrell and Carmencita David Padilla. “Current status of newborn screening worldwide: 2015”. Seminars in Perinatology 39.3 (2015): 171-187.
  10. Marsden D. “Newborn screening for metabolic disorders”. Journal Pediatrics 148.5 (2006): 577-584.
  11. Cardosa Martens IR and Sotelo Crúz N. “Hiperplasia suprarrenal congénita: diagnóstico y tratamiento en 20 casos”. Revista Mexicana de Pediatría 74.6 (2007): 251-256.
  12. Fernhoff PM. “Newborn screening for Genetic Disorders”. Pediatric Clinics of North America 56.3 (2009): 505-513.
  13. Vela-Amieva M., et al. “Frecuencia de enfermedades metabólicas congénitas susceptibles de ser identificadas por el tamiz neonatal”. Acta Pediátrica de México 30.3 (2009): 156-162.
  14. CENETEC. Tratamiento dietético nutricional del paciente pediátrico y adolescente con fenilcetonuria en 1°, 2° y 3er nivel de atención. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México (2016).
  15. CENETEC. Galactosemia. Tamizaje, diagnóstico, tratamiento médico de las complicaciones e intervención nutricional. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México (2017).
  16. IMSS. Deficiencia de glucosa 6 fosfato deshidrogenasa. Tamizaje, diagnóstico y tratamiento 1er, 2° y 3er nivel de atención. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México (2016).
  17. ISSSTE. Prevención, detección y diagnóstico de hipotiroidismo congénito en el primer nivel de atención. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México (2015).
  18. Secretaría de Salud. Tamizaje, diagnóstico y tratamiento del paciente con hiperplasia suprarrenal congénita por deficiencia de 21 hidroxilasa. Guía de Evidencias y Recomendaciones: Guía de Práctica Clínica. México (2014).
Citation: Alejandra Itzel Contreras Rivas and Gaston Eduardo Estudillo Jimenez. “Metabolic Screening: Experience in Second Level Attention Hospital”. EC Paediatrics 9.4 (2020): 123-128.

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