Perspective
Volume 5 Issue 2 - 2017
Influence to Autoimmune Processes of Patients Suffering from Osteoarthritis
Khaymenova GS*
Ukrainian Medical Stomatological Academy, Poltava city, Ukraine
*Corresponding Author: Khaymenova GS, Ukrainian Medical Stomatological Academy, Poltava city, Ukraine.
Received: December 27, 2016; Published: January 03, 2017
Citation: Khaymenova GS. “Influence to Autoimmune Processes of Patients Suffering from Osteoarthritis”. EC Orthopaedics 5.2 (2017): 32-33.
In the past few years. it has become more obvious that osteoarthritis (OA) is one of the most widespread chronic disabling diseases. According to different epidemiological reports. nearly 80% of the population by the age of 60 are suffering from OA. Herewith most of them have some form of movement restriction, and 25% of them are unable to take care of themselves independently in everyday life. It is noted that OA is a problem, which is widespread throughout Ukraine.
Lately, great importance in OA diagnostics has been devoted to investigate OA pathogenesis autoimmune components. In particular, that of hyaluronic acid antibodies (HAAB) and collagen antibodies (CAB). Since hyaluronic acid and collagen are the main components of the cartilaginous tissue matrix.
The goal of our study is to determine the benefits of magnesium oil for patients suffering from the autoimmune processes of osteoarthritis.
Testing was conducted at the rheumatology department of Poltava Regional Clinical Hospital of Sklifosovsky N.V.
30 patients were chosen for this study (11 men, 19 women, with an average age of 61 ± 7 years), who are suffering from OA in the poignant stage. Diagnose was determined by the guidelines of American Rheumatology Association criteria due to the clinical and radiological data complexes of OA. The main first group (I) (consisting of 15 patients) held physiotherapy courses of 10 sessions of electrophoresis in addition to Magnesium Oil application. The second (II) group of 15 patients served as control group. This group was given a course of electrophoresis with “Fastum Gel” applications.
According to the given goal special interest was taken in the examination of both HAAB and CAB levels in the blood by immunofluorescence analysis method before therapy began (outgoing data) and in dynamic treatment in the 21 days allotted for this study.
In the 21 days the HAAB and CAB levels decreased in both groups but their dynamic make up was different due to the application method (Table 1). Concentration of the HAAB and CAB in the first Group significantly decreased on average to 2.13 ± 0.32 units of optical density and 1.04 ± 0.13 units of optical density in accordance to outgoing data (t = 2.26; р < 0.05 і t = 2.29; р < 0.05. accordingly). Another situation was in Group II in the analysis of the HAAB and CAB levels. Within the 21 days of the test the HAAB and CAB levels decreased (2.95 ± 0.21 units of optical density and 1.75 ± 0.22 units of optical density. accordingly). But we haven’t determined statistically significant differences in comparison with outgoing data (3.54 ± 0.73 units of optical density and 2.43 ± 0.49 units of optical density): t = 0.97; p > 0.05. t = l. 28; р > 0.05 respectively.
Thus, we saw positive treatment in the autoimmune process which continued until the treatment end in both I and II group of our OA patients in our study.
Time of Blood Collection I Group «Magnesium Oil».
n = 15
ІІ Group «Fastum Gel».
n = 15
HAAB level CAB level HAAB level CAB level
Start Data 3.76 ± 0.76 2.28 ± 0.52 3.54 ± 0.73 2.43 ± 0.49
In 21 days after therapy beginning 2.13 ± 0.32* 1.04 ± 0.13* 2.95 ± 0.21 1.75 ± 0.22
t 2.26 2.29 0.77 1.28
Р < 0.05 < 0.05 > 0.05 > 0.05

Table 1: Comparison analysis of HAAB and CAB levels in the groups of OA diseased who received electrophoresis with Magnesium Oil and Fastum Gel. М ± m. units of optical density.
Remark: * – veracious differences with start data (р < 0.05).

But statistically significant differences in the HAAB and CAB levels between patients of Group I (the main group) and Group II (control group) in 21 days after treatment beginning (р < 0.05) were discovered. Positive therapeutic influence of Magnesium Oil was discovered to influence to autoimmune component of joints inflammation and tissue destruction. This was confirmed by decreasing the leading autoimmune markers of conjunctive tissue level antibodies for hyaluronic acid and collagen.
That, the course treatment with the Magnesium Oil allows the dramatic decreasing of autoimmune inflammation of conjunctive tissue marker levels in both the HAAB and CAB. The influence of Magnesium Oil to autoantibody levels in cases of OA shows proof of its anti-inflammation effect. and also doesn’t exclude its chondroprotector effect. Magnesium Oil helps to provide a stabilization point in the inflammation process. for added prevention of the progression and amplification of disease complications in cases of OA.
Copyright: © 2017 Khaymenova GS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 14, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.