Case Report
Volume 12 Issue 11 - 2021
Unicentric Castleman’s Disease with Multicentric Behavior: A Case Report
Raed M Alzyoud1*, Hamza M Al-Nsour1, Rawand M AlQtaishat1, Lina I Ghanmiyin1, Zeyad M Khalilah2, Motasem O Alsuweiti1, Mohammed D Al Nahar3 and Omar Ashokaibi4
1Pediatric Immunology, Allergy, and Rheumatology Division, Queen Rania Children’s Hospital, Amman, Jordan
2Pediatric Pulmonary Division, Queen Rania Children’s Hospital, Amman, Jordan
3Externship Physician, Queen Rania Children’s Hospital, Amman, Jordan
4Pathology Division, Princess Iman Research and Laboratory Science Center, Amman, Jordan
*Corresponding Author: Raed M Alzyoud, Pediatric Immunology, Allergy and Rheumatology section, Queen Rania Children’s Hospital, Amman, Jordan.
Received: September 09, 2021; Published: October 29, 2021


Castleman’s disease is a clinicopathological entity associated with lymphoproliferation. We report a case of a 13-year-old who was initially clinically suspected to have Behçet Disease (BD) (owing to clinical features at presentation), though was later histologically confirmed to have Castleman’s disease. This case report shows how unicentric Castleman’s disease can share behaviors similar to the multicentric disease.

Keywords: Unicentric Castleman Disease; Behçet Disease; Paraneoplastic Syndrome


  1. Frizzera G. “Castleman's disease and related disorders”. Seminars in Diagnostic Pathology 5 (1988): 346-364.
  2. Castleman B., et al. “Localized mediastinal lymph-node hyperplasia resembling thymoma”. Cancer 9 (1956): 822-830.
  3. Herrada J., et al. “The clinical behaviour of localized and multicentric Castleman disease”. Annals of Internal Medicine8 (1998): 657‐662.
  4. Bowne WB., et al. “The management of unicentric and multicentric Castleman's disease”. Cancer3 (1999): 706‐717.
  5. Munshi N., et al. “Use of a claims database to characterize and estimate the incidence rate for Castleman disease”. Leukemia and Lymphoma5 (2015): 1252-1260.
  6. González-García A., et al. “Clinical and pathological characteristics of Castleman disease: an observational study in a Spanish tertiary hospital”. Leukemia and Lymphoma14 (2019): 3442-3448.
  7. Talat N., et al. “Surgery in Castleman’s disease: a systematic review of 404 published cases”. Annals of Surgery4 (2012): 677-684.
  8. Xuanye Zhang., et al. “Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients”. Cancer Science1 (2018): 199-206.
  9. Yu L., et al. “Clinical and pathological characteristics of HIV- and HHV-8-negative Castleman disease”. Blood 12 (2017): 1658-1668.
  10. Fujimoto S., et al. “Tentative diagnostic criteria and disease severity classification for Castleman disease: A report of the research group on Castleman disease in Japan”. Modern Rheumatology 1 (2018): 161-167.
  11. Nikolskaia OV., et al. “Paraneoplastic pemphigus in association with Castleman’s disease”. British Journal of Dermatology 149 (2003): 1143‑11
  12. Hiroki Mochizuki., et al. “Overlap of IgG4-related Disease and Multicentric Castleman’s Disease in a Patient with Skin Lesions”. Internal Medicine 9 (2017): 1095-1099.
  13. Zumi Y., et al. “Multicentric Castleman disease mimicking IgG4-related disease: A case report”. Modern Rheumatology 21 (2017): 174-177.
Citation: Raed M Alzyoud., et al. “Unicentric Castleman’s Disease with Multicentric Behavior: A Case Report”. EC Orthopaedics 12.11 (2021): 57-62.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 15, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.