Research Article
Volume 12 Issue 11 - 2021
Efficiency of Ossein-Hydroxyapatite Complex in the Treatment of Patients with Non-Unions Complicated by Posttraumatic Osteoporosis
SM Kutepov1, SV Gyulnazarova1* and OA Kuznetzova2
1Ural State Medical University of the Health Ministry of the Russian Federation, Ekaterinburg, Russia
2Ural Institute of Traumatology and Orthopaedics Named After V.D. Chaklin, Ekaterinburg, Russia
*Corresponding Author: SV Gyulnazarova, Ural State Medical University of the Health Ministry of the Russian Federation, Ekaterinburg, Russia.
Received: September 13, 2021; Published: October 28, 2021




Abstract

Comparative analysis of the results of application of ossein-hydroxyapatite complex (OHC) and calcium with vitamin D3 together with surgical treatment of patients with hypoplastic non-unions of femur and shin, complicated by osteoporosis was performed. Patients were operated by open trans osseous osteosynthesis with Ilizarov apparatus without the autobone plasty. After surgery one group of patients had received OHC for 6 months as it was recommended by authors (Patent RF № 2423983). Second group of patients had received calcium with vitamin D3 during the same period of time. Third group did not receive any medicaments. Non-unions of all patients were eliminated without repeated surgery. Analysis of union-time showed the use of OHC or calcium with vitamin D3 promoted significant reduction of the non-union consolidation time. OHC influenced also on bone mineral density of damaged leg positively. It contributed optimization to process of the bone remodeling and provided regression of osteoporosis even in time of the main pathology treatment and later, in 1.5 years of subsequent observation. Results of this investigations has shown high efficiency of OHC in treatment of non-unions complicated by posttraumatic (immobilized) osteoporosis. The use of OHC in treatment of this very difficult orthopaedical pathology is reasonable and efficient.

Keywords:Non-Union; Femur; Shin; Osteoporosis; Ilizarov Apparatus; Ossein-Hydroxyapatite Complex; Bone Mineral Density; Standard Deviationn

References

  1. Selitzhkiy A.V. and Kezlya O.P. “Choice of effective pharmacological therapy in patients with complex multifragmental diaphyseal tibial fractures/ VII International conference”. Problem of Osteoporosis in Traumatology and Orthopaedics (2018): 186-187.
  2. Gorin V.V., et al. “Intramedullary osteosyntesis of non-unions femur and tibia bones”. //XI Meeting of Russian Traumatologists and Orthropaedists, 11-13 April,2018. Vol. II, - P. 222-223, Russia.
  3. Gyulnazarova S.V., Kuznetzova O.A. “Evaluation of mineral bone density in non-unions and delayed fractures of long bone legs”. Genij Orthopedii 1 (2002): 161-162.
  4. Gyulnazarova S.V. «Immobilized osteoporosis: pathogenesis and principles non-unions treatment on this background»// Bull. traum. orthop. n.a. V.D. Chaklin 2 (2010): 5-12
  5. Lyritis E.P. “Fracture healing and antiosteoporotic treatment”. //Medicographia 32 (2010). –P. 79-85.
  6. Jorgensen N.R., Schwartz P. “Influence of anti-osteoporosis medications on fracture healing”. / Current Osteoporosis Reports 9.3 (2011). – P. 149-155.
  7. Alegre D.N., et al. “Possible benefits of strontium renelate in complicated long bone fractures”. Rheumatology International 32.2 (2012): - P.432-433.
  8. Goldhahn J., et al. “Implications for fracture healing of current and new osteoporosis treatments: an ESCEO consensus paper”. /Calcified Tissue International 90 (2012): - P.343-353.
  9. Hegde V., et al. “Effect of osteoporosis medications on fracture healing”. /Osteoporosis International 27 (2016): -P.861-871.
  10. A. Kuznetzova, S.V. Gyulnazarova. “Patent 24233983 RF. Method of osteoporosis correction in treatment of non-joining fractures and non-unions”. - Bull. 20 (2011):- P. 9.
  11. Eyres K.S., Kanis J.A. “Bone loss after tibial fracture”. /Journal of Bone and Joint Surgery Vol. 77 (1995): - P. 473-478.
  12. Pobel E.A. “Fracture – a risk factor for development and progression of osteopenia and osteoporosis”. //Osteoporosis and Osteopathy 3 (2013): - P. 28-34.
  13. Castello-Branco C., et al. “Efficacy of ossein-hydroxyapatite complex compared with calcium carbonate to prevent bone loss: a metaanalysis”. Menopause Vol. 16.5 (2009): - P.984-991.
  14. Heyfets L.M., et al. “Ostrogenon for treatment fractures of radius distal part of in patients with second osteoporosis”. //Therapy Archive 3 (2007): - P. 52-54.
  15. Lazarev A.F., Solod E.I. “Fractures of proximal part of femur with osteoporosis: endoprosthetics or osteosynthesis?” // VI Int. Conference. “Problem of Osteoporosis in Traumatology and Orthopaedics” 2-3 Febr. 2015. – P. 65-66.
  16. Solod E.I. “Features of surgical treatment in patients with fractures and disruption of bone metabolism”. //Rheumat, trauma and orthop. 1 (2017):- P. 50-52.
  17. Rodionova S.S., et al. “Experience of the osteogenon using in traumatology and orthopaedics”.// Bull. traum. orthop. n.a. N.N. Priorov 4 (2001): - P. 41-46.
  18. Korzh N.A., et al. “Clinico-metabolic aspects using osteogenon in patients with fractures long bone”. // Orthop., traum. and prosthetics 2 (2003): - P. 94-99.
  19. Povoroznuk V.V., et al. “Ossein-hydroxyapatite compound (osteogenon) in prevent and treatment of osteoporosis and its complications”.// Orthopaedics, Traumatology and Prosthetics 1 (2004): - P.1-7.
  20. Rodionova S.S., Krivova A.V. “Osteogenon with combined treatment of fractures”. //Difficult Patient 5 (2007): - P. 15-18.
  21. Rodionova S.S., et al. “Method of increasing of bone mass in fractures (textbook for physicians). M. CITO n.a. N.N. Priorov (2007): - P. 12.
  22. Rodionova S.S., Torgashin A.N. “Practical recommendations by reablement and restoration of activity after fractures [Electron resources]. – Regime (2015).
  23. Korzh N.A., Deduh N.V. “Employment Ossein-hydroxyapatite compound in treatment of osteoporosis and fractures”. /Orthopaedics, Traumatology and Prosthetics 2 (2016): - P. 121-129.
  24. Gyulnazarova S.V., Kuznetzova O.A. “Ossein-hydroxyapatite compound in treatment patients with non-unions femur and shin bones complicated by systematic osteoporosis”. //Bull. traumat. orthop. n.a. N.N. Priorov 2 (2006): - P. 21-24.
  25. Gyulnazarova S.V., Kuznetzova O.A. «Treatment of long non-unions with osteoporosis by Ilizarov method» [Abstracts] 4-th Meeting of ASAMI International 11-14 Oct. Kyoto, (2006): - P. 298.
  26. Kuznetsova O.A., Gyulnazarova S.V. “Efficiency of osteogenon in the treatment of patients with nonunions complicated by immobilized osteoporosis”./ Bull. Traum. Orthop. Urals 1-2 (2013):- P. 30-34.
  27. Trifonova E.B., et al. “Effect of ossific therapy to bone remodeling in patients with osteoporosis”.// Modern problems of science and education” (2015): 3.
Citation: SV Gyulnazarova., et al. “Efficiency of Ossein-Hydroxyapatite Complex in the Treatment of Patients with Non-Unions Complicated by Posttraumatic Osteoporosis”. EC Orthopaedics 12.11 (2021): 29-35.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 15, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.