Literature Review
Volume 12 Issue 10 - 2021
Research on Hip Fracture Risk in Vitamin B12 Deficient Older Adults
Ray Marks*
Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, USA
*Corresponding Author: Ray Marks, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, USA.
Received: September 20, 2021; Published: September 30, 2021




Abstract

Introduction: Bone diseases, such as osteoporosis, as well as falls, when combined are especially prevalent among the older population. Associated with varying degrees of bone thinning, fragility, and increased susceptibility to fracture due to sarcopenia and other neuromuscular factors, preventing hip fractures is of high importance to all populations with aging citizens. Unfortunately, relatively little has been done over time to reduce the degree of bone destruction, or thinning, among other bone and muscle associated pathological changes underpinning one or multiple hip fracture occurrences.

Aim: This mini review focuses on the topic of hip fracture risk and prevention from the viewpoint of vitamin B12, a possible unexplored correlate of clinical relevance.

Methods: Articles of any genre concerning the possible association of vitamin B12 with bone health, muscle mass and function, frailty, and falls were specifically sought.

Results: A limited volume or research both tends to support or negate a role for vitamin B12 in the context of hip fracture risk and occurrences depending on what is studied and how it is studied and interpreted.

Conclusion: Sufficient rationale for a possible moderating or mediating role for vitamin B12 in some cases among the elderly who are malnourished, have malabsorption problems, and certain cardiovascular signs appears warranted.

Keywords: Bone; Cobalamin; Elderly; Falls; Hip Fracture; Osteoporosis; Sarcopenia; Vitamin B12

References

  1. McLean RR., et al. “Plasma B vitamins, homocysteine, and their relation with bone loss and hip fracture in elderly men and women”. Journal of Clinical Endocrinology and Metabolism6 (2008): 2206-2212.
  2. Dai Z and Koh WP. “B-vitamins and bone health--a review of the current evidence”. Nutrients5 (2015): 3322-3346.
  3. Mithal A., et al. “Nutrition Working Group. “Impact of nutrition on muscle mass, strength, and performance in older adults”. Osteoporosis International 24 (2013): 1555-1566.
  4. Tanaka K., et al. “Insufficiency of B vitamins with its possible clinical implications”. Journal of Clinical Biochemistry and Nutrition1 (2000): 19-25.
  5. Swart KM., et al. “A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF Study”. Calcified Tissue International1 (2016): 18-27.
  6. Wolffenbuttel BHR., et al. “Association of vitamin B12, methylmalonic acid, and functional parameters”. Netherlands Journal of Medicine1 (2020): 10-24.
  7. Wee AK. “Serum folate predicts muscle strength: a pilot cross-sectional study of the association between serum vitamin levels and muscle strength and gait measures in patients >65 years old with diabetes mellitus in a primary care setting”. Nutrition Journal1 (2016): 89.
  8. Bulut EA., et al. “Vitamin B12 deficiency might be related to sarcopenia in older adults”. Experimental Gerontology 95 (2017): 136-140.
  9. Gedmantaite A., et al. “Associations between diet and handgrip strength: a cross-sectional study from UK Biobank”. Mechanisms of Ageing and Development 189 (2020): 111269.
  10. Macêdo LLG., et al. “Vitamin B12, bone mineral density and fracture risk in adults: a systematic review”. Journal of the Brazilian Medical Association9 (1992): 801-809.
  11. He T., et al. “The association of homocysteine, folate, vitamin B12, and vitamin B6 with fracture incidence in older adults: a systematic review and meta-analysis”. Annals of Translational Medicine14 (2001): 1143.
  12. Torbergsen AC., et al. “Micronutrients and the risk of hip fracture: case-control study”. Clinical Nutrition2 (2017): 438-443.
  13. Gjesdal CG., et al. “Plasma homocysteine, folate, and vitamin B12 and the risk of hip fracture: the Hordaland Homocysteine Study”. Journal of Bone and Mineral Research 5 (2007): 747-756.
  14. Tucker KL., et al. “Low plasma vitamin B12 is associated with lower BMD: the Framingham Osteoporosis Study”. Journal of Bone and Mineral Research 1 (2005): 152-158.
  15. Inoue T., et al. “Undernutrition, sarcopenia, and frailty in fragility hip fracture: advanced strategies for improving clinical outcomes”. Nutrients12 (2020): 3743.
  16. Buesing S., et al. “Vitamin B12 as a treatment for pain”. Pain Physician 1 (2019): E45-E52.
  17. Matteini AM., et al. “Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty”. Journal of Nutrition Health and Aging 1 (2010): 73-77.
  18. Meyer M., et al. “Impact of malnutrition and vitamin deficiency in geriatric patients undergoing orthopedic surgery”. Acta Orthopaedica3 (2021): 358-363.
  19. Young J. “Rapid response to: prevention of falls in older people living in the community”. British Medical Journal 353 (2016): i1419.
  20. Watson J., et al. “Consequences of inadequate intakes of vitamin A, vitamin B 12, vitamin D, calcium, iron, and folate in older persons”. Current Geriatrics Reports2 (2018): 103-113.
  21. Shipton MJ and Thachil J. “Vitamin B12 deficiency - a 21st century perspective”. Clinical Medicine 2 (2015): 145-150.
  22. Pannérec A., et al. “Vitamin B12 deficiency and impaired expression of amnionless during aging”. Journal of Cachexia, Sarcopenia, and Muscle1 (2018): 41-52.
  23. Van Wijngaarden JP., et al. “Vitamin B12, folate, homocysteine, and bone health in adults and elderly people: a systematic review with meta-analyses”. Journal of Nutrition and Metabolism 2013 (2013): 486186.
  24. Herrmann W and Obeid R. “Causes and early diagnosis of vitamin B12 deficiency”. Deutsches Ärzteblatt International40 (2008): 680-685.
  25. Calderón-Ospina CA and Nava-Mesa MO. “B vitamins in the nervous system: current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin”. CNS Neuroscience and Therapy1 (2020): 5-13.
  26. Green R., et al. “Vitamin B12 deficiency”. Nature Reviews: Disease Primers 3 (2017): 17040.
  27. Soh Y and Won CW. “Association between frailty and vitamin B12 in the older Korean population”. Medicine (Baltimore)43 (2020): e22327.
  28. O’Leary F and Samman S. “Vitamin B12 in health and disease”. Nutrients3 (2010): 299-316.
  29. Wolffenbuttel BHR., et al. “The many faces of cobalamin (vitamin B12) deficiency”. Mayo Clinic Proceedings: Innovations, Quality, and Outcomes2 (2019): 200-214.
  30. Stone KL., et al. “Effect of combination folic acid, vitamin B6, and vitamin B12 supplementation on fracture risk in women: a randomized, controlled trial”. Journal of Bone and Mineral Research12 (2017): 2331-2338.
  31. Dokuzlar O., et al. “Association between serum vitamin B12 level and frailty in older adults”. Northern Clinics of Istanbul1 (2017): 22-28.
  32. Van Dijk M., et al. “Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice”. Journal of Cachexia, Sarcopenia, and Muscle1 (2018): 146-159.
  33. Egan W., et al. “Vitamin B12 deficiency-induced neuropathy secondary to prolonged recreational use of nitrous oxide”. American Journal of Emergency Medicine9 (2018): 1717.e1-1717.e2.
  34. Verlaan S., et al. “Nutritional status, body composition, and quality of life in community-dwelling sarcopenic and non-sarcopenic older adults: a case-control study”. Clinical Nutrition1 (2017): 267-274.
  35. Takahashi F., et al. “Vitamin intake and loss of muscle mass in older people with type 2 diabetes: a prospective study of the KAMOGAWA-DM cohort”. Nutrients 7 (2021): 2335.
  36. Kalimeri M., et al. “Folate and vitamin B-12 status is associated with bone mineral density and hip strength of postmenopausal Chinese-Singaporean women”. JBMR Plus 10 (2020): e10399.
  37. Ao M., et al. “Relationship between homocysteine, folate, vitamin B12 and physical performance in the institutionalized elderly”. Journal of Nutritional Science and Vitaminology 1 (2019): 1-7.
  38. Behrouzi P., et al. “Dietary intakes of vegetable protein, folate, and vitamins B-6 and B-12 are partially correlated with physical functioning of Dutch older adults using copula graphical models”. Journal of Nutrition 3 (2020): 634-643.
  39. Lewerin C., et al. “Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden”. Osteoporosis International1 (2014): 1311-1340.
  40. Majumder A., et al. “Causes and consequences in skeletal muscle myopathy”. Journal of Cell Biochemistry8 (2017): 2108-2117.
  41. Franques J., et al. “Characteristics of patients with vitamin B12-responsive neuropathy: a case series with systematic repeated electrophysiological assessment”. Neurology Research6 (2019): 569-576.
  42. Mizrahi EH., et al. “Low borderline levels of serum vitamin B12 may predict cognitive decline in elderly hip fracture patients”. Israel Medical Association Journal5 (2017): 305-308.
  43. Berlie HD and Garwood CL. “Diabetes medications related to an increased risk of falls and fall-related morbidity in the elderly”. Annals of Pharmacotherapy4 (2010): 712-717.
  44. Gwathmey KG and Grogan J. “Nutritional neuropathies”. Muscle Nerve1 (2020): 13-29.
  45. Singh P., et al. “Maternal vitamin B12 in mice positively regulates bone, but not muscle mass and strength in post-weaning and mature offspring”. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology6 (2020): R984-R993.
  46. Pawlak R. “Vitamin B12 status is a risk factor for bone fractures among vegans”. Medical Hypotheses 153 (2021): 110625.
  47. Meyer HE., et al. “Association of high intakes of vitamins B6 and b12 from food and supplements with risk of hip fracture among postmenopausal women in the Nurses' Health Study”. JAMA Network Open5 (2019): e193591.
  48. Dhonukshe‐Rutten., et al. "Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people”. Journal of Bone and Mineral Research6 (2005): 921-929.
  49. Jatoi S., et al. “Low vitamin B12 levels: an underestimated cause of minimal cognitive impairment and dementia”. Cureus2 (2020): e6976.
  50. Tangney CC., et al. “Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination”. Neurology13 (2011): 1276-1282.
  51. Dharmarajan TS., et al. “Vitamin B12 deficiency. Recognizing subtle symptoms in older adults”. Geriatrics (Basel, Switzerland)3 (2003): 30-34.
  52. Mosen DM., et al. “Food insecurity associated with self-reported falls among medicare advantage members”. Population Health Management6 (2019): 536-539.
  53. Allen LH., et al. “Biomarkers of Nutrition for Development (BOND): vitamin B-12 review”. Journal of Nutrition4 (2018): 1995S-2027S.
  54. Marks R. “Hip fracture epidemiological trends, outcomes, and risk factors, 1970-2009”. International Journal of General Medicine 3 (2010): 1-17.
  55. Langan RC and Goodbred AJ. “Vitamin B12 deficiency: recognition and management”. American Family Physician6 (2007): 384-389.
  56. Ng TP., et al. “Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from the Singapore Longitudinal Ageing Study”. The American Journal of Clinical Nutrition6 (2012): 1362-1368.
  57. Vincenti A., et al. “Perspective: practical approach to preventing subclinical b12 deficiency in elderly population”. Nutrients6 (2021): 1913.
  58. De Martinis M., et al. “Hyperhomocysteinemia is associated with inflammation, bone resorption, vitamin B12 and folate deficiency and mthfr c677t polymorphism in postmenopausal women with decreased bone mineral density”. International Journal of Environmental Research and Public Health12 (2020): 4260.
  59. Stone KL., et al. “Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study”. Journal of Clinical Endocrinology and Metabolism3 (2004): 1217-1221.
  60. Tardy AL., et al. “Vitamins and minerals for energy, fatigue and cognition: a narrative review of the biochemical and clinical evidence”. Nutrients1 (2020): 228.
  61. Spence JD. “Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke”. Nutrition Research 2 (2016): 109-116.
  62. Health Quality Ontario. “Vitamin B12 and cognitive function: an evidence-based analysis”. Ontario Health Technology Assessment Service 23 (2013): 1-45.
  63. Porter K., et al. “Causes, consequences and public health implications of low B-vitamin status in ageing”. Nutrients 8 (2016): 725.
  64. Van de Lagemaat EE., et al. “Vitamin B12 in relation to oxidative stress: a systematic review”. Nutrients 11 (2019): 482.
Citation: Ray Marks. “Research on Hip Fracture Risk in Vitamin B12 Deficient Older Adults”. EC Orthopaedics 12.10 (2021): 60-72.

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