Research Article
Volume 12 Issue 9 - 2021
Seropositivity of HTLV-1 Infection in Inflammatory Arthritis
Zahra Rezaieyazdi1, Maryam Hami3, Nima Zafari2, Mahla Velayati2 and Kamila Hashemzadeh1*
1Rheumatic Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Kidney Transplantation Complications Research Center, Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Kamila Hashemzadeh, Rheumatic Diseases Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Received: June 07, 2021; Published: August 28, 2021




Abstract

Background: Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus. It is proposed that in endemic regions of the world, autoimmune disorders related with HTLV-1 contamination such as rheumatoid arthritis are more common. The infiltration of T lymphocyte and hyperplasia of synovial lining cells have also been reported in rheumatoid arthritis and seronegative spondyloarthropathies.

Aim: In this study, we evaluated the etiological relationship between HTLV-1 and inflammatory arthropathies such as rheumatoid arthritis (RA) and seronegative spondyloarthropathy (SPA) in northeastern Iran as this virus is endemic.

Methods: Anti-HTLV-1 antibody was measured in 204 individuals (81 with RA, 43 with SPA and 80 healthy controls). HTLV-1 antibody was evaluated by enzyme-linked immunosorbent assay (ELISA) in serum. For all positive ELISA samples of HTLV-1 infection, Western Blot was performed to confirm the results. Each anti-HTLV-1 and anti-HTLV-2 positive specimens were measured simultaneously to make sure that the test results are true.

Results: The incidence of HTLV-1 contamination in RA group was 6.2%, in SPA group was 2.3% and in control group was 51%. There was not any statistical difference among RA, SPA patients and controls according to the number of HTLV-1 seropositive samples (P = 005).

Conclusion: In the present study, we did not find any correlation between HTLV-1 infection and inflammatory arthropathy such as RA and SPA, which suggests that differences in ethnicity may subscribe to this subject. Geographical and environmental factors should be also considered.

Keywords: Seropositivity; Human T-Cell Lymphotropic Virus Type 1 (HTLV-1); Inflammatory Arthritis; Rheumatoid Arthritis; Seronegative Spondyloarthropathies

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Citation: Kamila Hashemzadeh., et al. “Seropositivity of HTLV-1 Infection in Inflammatory Arthritis”. EC Orthopaedics 12.9 (2021): 02-07.

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