Research Article
Volume 12 Issue 8 - 2021
Skull Bone Tumors: A Seven Year Retrospective Study in Tertiary Care Centre
Supriya Prasad1, Jayasree K1*, Sindhu Nair P1, Sreejith Nair2, Priyakumari T3 and Venugopal M4
1Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, India
2Division of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, India
3Division of Pediatric Oncology, Regional Cancer Centre, Thiruvananthapuram, India
4Division of Imageology, Regional Cancer Centre, Thiruvananthapuram, India
*Corresponding Author: Jayasree K, Division of Pathology, Regional Cancer Centre, Thiruvananthapuram, India.
Received: May 29, 2021; Published: July 28, 2021




Abstract

Introduction: Primary skull bone tumors are very rare and account for less than 1% of all bone tumors. They include a spectrum of lesions, which may be benign or malignant.

Objective: These tumors have not been reported systematically in literature, as majority of the published studies are single case reports. Hence, through this study we aim to evaluate the spectrum of benign and malignant tumours of skull bones in different age groups and locations.

Materials and Methods: This a retrospective study. A total of 29 cases over a period of seven years from 1st January 2011 to 31st December 2017 are included in this study.

Results and Conclusion: There were a total of 29 cases of the primary bone tumors of the skull, over a period of 7 years. The mean age of the patients was 25.4 years with slight female predilection. Majority of the patients were adults, but a substantial number (n = 12) were in the pediatric age group. Malignant cases constituted approximately 90% of cases. The most common tumor was osteosarcoma, with predominance in the pediatric population and located in the calvarial bones. Among the adults the most common tumor was chordoma followed by chondrosarcoma. A multidisciplinary approach involving the treating physician, the radiologist and the pathologist is advocated for proper typing and management of these tumors.

 

Keywords: Skull; Bone; Tumors; Malignant

References

  1. Lau DP., et al. “Chondrosarcoma of the petrous apex. Dilemmas in diagnosis and treatment”. The Journal of Laryngology and Otology4 (1997): 368-371.
  2. Liu H., et al. “Skull bone tumor: a review of clinicopathological and neuroimaging characteristics of 426 cases at a single center”. Cancer Communications1 (2019): 8.
  3. Kakkar A., et al. “Primary Bone Tumors of the Skull: Spectrum of 125 Cases, with Review of Literature”. Journal of Neurological Surgery Part B: Skull Base04 (2016): 319-325.
  4. Kassir R., et al. “Osteosarcoma of the Head and Neck: Meta-analysis of Nonrandomized Studies”. The Laryngoscope1 (1997): 56-61.
  5. Fernandes G., et al. “Primary osteosarcoma of the cranial vault”. Radiologia Brasileira4 (2017): 263-265.
  6. Mascarenhas L., et al. “Skull osteosarcoma: illustrated review”. Acta Neurochirurgica11 (2004): 1235-1239.
  7. Chander B., et al. “Primary osteosarcoma of the skull. A report of 3 cases”. Journal of Neurosurgical Sciences 47 (2003): 177-181.
  8. Patel A., et al. “Radiation-induced osteosarcomas of the calvarium and skull base”. Cancer10 (2010): 2120-2126.
  9. Agarwal G., et al. “Osteosarcoma as a Second Malignant Disease in a Case of Bilateral Retinoblastoma”. Indian Journal of Otolaryngology and Head and Neck Surgery1 (2011): 115-117.
  10. Reddy Kundoor VK., et al. “A typical radiographic presentation of osteosarcoma arising from skull and scapula: A rare case report”. Journal of Oral and Maxillofacial Radiology 4 (2016): 14-17.
  11. Ellison DW., et al. “Tumors: non-neuroepithelial tumours and secondary effects”. In: Lowe S, Louis DN, Ellison DW, eds. Greenfield’s Neuropathology. London, United Kingdom: Edward Arnold (2008): 2002-2182.
  12. Stacchiotti S and Sommer J. “Chordoma Global Consensus Group. Building a global consensus approach to chordoma: a position paper from the medical and patient community”. The Lancet Oncology2 (2015): e71-e83.
  13. Stacchiotti S and Sommer J. “Building a global consensus approach to chordoma: a position paper from the medical and patient community”. The Lancet Oncology2 (2015): e71-e83.
  14. Cianfriglia F., et al. “Intracranial malignant cartilaginous tumours. Report of two cases and review of literature”. Acta Neurochirurgica1-2 (1978): 163-175.
  15. Bloch O., et al. “A systematic review of intracranial chondrosarcoma and survival”. Journal of Clinical Neuroscience12 (2009): 1547-1551.
  16. Xu J., et al. “Mesenchymal Chondrosarcoma of Bone and Soft Tissue: A Systematic Review of 107 Patients in the Past 20 Years”. Plos One4 (2015): e0122216.
  17. Mobley B., et al. “Peripheral primitive neuroectodermal tumor/Ewing's sarcoma of the craniospinal vault: case reports and review”. Human Pathology7 (2006): 845-853.
Citation: Jayasree K., et al. “Skull Bone Tumors: A Seven Year Retrospective Study in Tertiary Care Centre”. EC Orthopaedics 12.8 (2021): 25-33.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


November Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 09, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.