Literature Review
Volume 12 Issue 6 - 2021
Melatonin and Osteoarthritis: An Overlooked Mediator?
Ray Marks*
Department of Health and Behavior Studies, Teachers College, Columbia University, NY, United States
*Corresponding Author: Marks Ray, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, United States.
Received: May 12, 2021; Published: May 24, 2021


Introduction: Osteoarthritis, a prevalent chronic disabling disease, is also an independent risk factor for COVID-19 infections among the elderly.

Aim: To examine what is known about the endocrine hormone melatonin and its possible utility for intervening in the osteoarthritis disability cycle, potentially heightened in the context of COVID-19 and its persistence and restrictions.

Methods: The PUBMED electronic data base was searched in its entirety, from 1992 - 2021 using the key terms: melatonin and osteoarthritis.

Results: Very few clinical studies on this topic prevail, even though almost all preclinical studies imply a favorable role for melatonin in enhancing osteoarthritis pathology, as well as COVID-19 immunity. Conversely, a deficit in melatonin appears associated with many features of osteoarthritis pathology, as well as its extra-articular symptoms, such as impaired sleep.

Conclusion: Melatonin has potent antioxidant, analgesic, regenerative, and anti-inflammatory properties that should be studied further in the context of efforts to improve the outlook for many older osteoarthritis sufferers, especially those residing in the community, and affected by the COVID-19 pandemic lockdown restrictions.

Keywords: Articular Cartilage; Bone; COVID-19; Inflammation; Melatonin; Osteoarthritis; Pain; Prevention


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Citation: Ray Marks. “Melatonin and Osteoarthritis: An Overlooked Mediator?”. EC Orthopaedics 12.6 (2021): 01-09.

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