Review Article
Volume 12 Issue 4 - 2021
The Role of Radiotherapy in Post-Operative Bone Metastases
Lokesh Kumar Yogi1* and Fariba Soltani-Mayvan2
1Orthopaedic Surgeon, Dr. VM Government Medical College and Hospital, Solapur, MH, India
2Radiotherapy Technician, Reza Radiation Oncology Center, 19th Misagh BLV. Namayeshgah BLV, Mashhad, Iran
*Corresponding Author: Lokesh Kumar Yogi, Orthopaedic Surgeon, Dr. VM Government Medical College and Hospital, Solapur, MH, India.
Received: February 01, 2021; Published: March 27, 2021




Abstract

Background: Bone metastases are when a cancer spread to the bones. It is estimated that they arise in 14 - 70% of all tumour patients, while it was reported that they occur in 70 - 85% patients in autopsy material. Bone metastases are mainly associated to an overstimulation of osteoclasts or osteoblasts causing a lytic or blastic lesion, respectively. Metastatic bone lesions prone for pathologic fracture leading to subsequent decrease the mobility, quality of life (QOL).  

Results: A best result of post-operative RT requires a multidisciplinary approach and a close cooperation between radiation, surgical and clinical oncology. In order to ensure a precise diagnosis and proper integration of systematic and local treatments a well-experienced multidisciplinary team (orthopaedic surgeons, radiotherapist and general surgeon) required.

Conclusion: Patients with painful bone metastases usually receive RT as an acceptable local treatment. Radiation therapy (RT) is performed primarily to reduce tumor size, relieve pain.

Keywords: Bone metastases; RT; Quality of Life

References

    1. Vakaet LA and Boterberg T. “Pain control by ionizing radiation of bone metastasis”. The International Journal of Developmental Biology 48 (2004): 599-606.
    2. Wu JS., et al. “Supportive Care Guidelines Group of Cancer Care Ontario. Radiotherapy fractionation for the palliation of uncomplicated painful bone metastases - an evidence-based practice guideline”. BMC Cancer 4 (2004): 71.
    3. Sahgal A., et al. “Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases”. International Journal of Radiation Oncology, Biology, Physics 74 (2009): 723-731.
    4. Goblirsch MJ., et al. “Biology of bone cancer pain”. Clinical Cancer Research 12 (2006): 6231s-6235s.
    5. Nielsen OS., et al. “Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases”. Radiotherapy and Oncology 47 (1998): 233-240.
    6. Gaze MN., et al. “Pain relief and quality of life following radiotherapy for bone metastases: a randomised trial of two fractionation schedules”. Radiotherapy and Oncology 45 (1997): 109-116.
    7. Hird A., et al. “Determining the incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: results from three Canadian cancer centers”. International Journal of Radiation Oncology, Biology, Physics 75 (2009): 193-197.
    8. Loblaw DA., et al. “Pain flare in patients with bone metastases after palliative radiotherapy--a nested randomized control trial”. Support Care Cancer 15 (2007): 451-455.
    9. Palma DA., et al. “The oligometastatic state - separating truth from wishful thinking”. Nature Reviews Clinical Oncology 11 (2014): 549-557.
    10. Steenland E., et al. “The effect of a single fraction compared to multiple fractions on painful bone metastases: a global analysis of the Dutch Bone Metastasis Study”. Radiotherapy and Oncology 52 (1999): 101-109.
    11. Wang M., et al. “Molecular mechanisms and clinical management of cancer bone metastasis”. Bone Research 8 (2020): 30.
    12. Fang J and Xu Q. “Differences of osteoblastic bone metastases and osteolytic bone metastases in clinical features and molecular characteristics”. Clinical and Translational Oncology3 (2015): 173-179.
    13. Verron E., et al. “Therapeutic strategies for treating osteolytic bone metastases”. Drug Discovery Today9 (2014): 1419-1426.
    14. Coleman RE., et al. “Bone metastases”. Abeloff's Clinical Oncology (2020): 809-830.
    15. J Woodward E and E Coleman R. “Prevention and treatment of bone metastases”. Current Pharmaceutical Design27 (2010): 2998-3006.
    16. Shupp AB., et al. “Cancer metastases to bone: concepts, mechanisms, and interactions with bone osteoblasts”. Cancers6 (2018): 182.
    17. Maisano R., et al. “Novel therapeutic approaches to cancer patients with bone metastasis”. Critical Reviews in Oncology/Hematology 40 (2001): 239-250.
    18. Gerber DE and Chan TA. “Recent advances in radiation therapy”. American Family Physician 78 (2008): 1254-1262.
    19. McDonald R., et al. “Effect of radiotherapy on painful bone metastases: A secondary analysis of the NCIC clinical trials group symptom control trial SC.23”. JAMA Oncology (2017).
    20. Townsend PW., et al. “Role of postoperative radiation therapy after stabilization of fractures caused by metastatic disease”. International Journal of Radiation Oncology 31 (1995): 43-49.
    21. Patchell RA., et al. “Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial”. Lancet9486 (2005): 643-648.
    22. Huisman M., et al. “Effectiveness of reirradiation for painful bone metastases: a systematic review and meta-analysis”. International Journal of Radiation Oncology* Biology* Physics1 (2012): 8-14.
    23. Chow E., et al. “Palliative radiotherapy trials for bone metastases: a systematic review”. Journal of Clinical Oncology11 (2007): 1423-1436.
    24. Rich SE., et al. “Update of the systematic review of palliative radiation therapy fractionation for bone metastases”. Radiotherapy and Oncology3 (2018): 547-557.
    25. Mcquay H., et al. “Radiotherapy for painful bone metastases: a systematic review”. Clinical Oncology 9 (1997): 150-154.
    26. Hartsell WF., et al. “Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases”. Journal of the National Cancer Institute 97 (2005): 798-804.
    27. Lutz S., et al. “Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline”. International Journal of Radiation Oncology, Biology, Physics 79 (2011): 965-976.
    28. Chow E., et al. “Single versus multiple fractions of repeat radiation for painful bone metastases: A randomised, controlled, non-inferiority trial”. The Lancet Oncology 15 (2014): 164-171.
    29. Van Der Linden YM., et al. “Dutch Bone Metastasis Study Group. Single fraction radiotherapy is efficacious: a further analysis of the Dutch Bone Metastasis Study controlling for the influence of retreatment”. International Journal of Radiation Oncology, Biology, Physics 59 (2004): 528-537.
    30. McDonald R., et al. “Incidence of pain flare in radiation treatment of bone metastases: A literature review”. The Journal of Bone Oncology 3 (2014): 84-89.
Citation: Lokesh Kumar Yogi and Fariba Soltani-Mayvan. “The Role of Radiotherapy in Post-Operative Bone Metastases”. EC Orthopaedics 12.4 (2021): 28-32.

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