Research Article
Volume 12 Issue 4 - 2021
Effect of Aerobic Exercise on CD4 Cell among People Living with HIV: Randomized Control Trial
Girma Tilahun1*, Temesgen Tilahun2, Soumitra Mondal1, Mohamud Abdulkedar2, Amdihun Yusuf3, Abdisa Gemechu3 and Edosa Jabesa4
1Assistant Professor, Department of Sport Studies, Wollega University, Ethiopia
2Associate Professor, Medical college, Wollega University Referral Hospital Medical Director, Ethiopia
3Lecturer, Nekemte Collage of Teacher Education, Ethiopia
4Lecturer, Wollega University, Sport Studies Department, Ethiopia
*Corresponding Author: Girma Tilahun, Assistant Professor, Department of Sport Studies, Wollega University, Ethiopia.
Received: February 16, 2021; Published: March 27, 2021


Objective: The main objective of this study was to see the effect of aerobic exercise among people with HIV.

Methods: The area where study was conducted Nekemte. Fifty eight subjects were selected from those met the inclusion criteria. The subject of the study was grouped into control and experimental. Before subjects were expose for aerobic exercise pre-test result were taken in order to compere intervention effect. Aerobic exercise of moderate intensity were given to experimental group whereas control group attend their ART and regularly participated on their activity. To conduct this study ethical clearance was collated from Health Research and Ethical Review. Data gathered within three months were analyzed by SPSS version 20. Significance level was set at P < 0.05.

Result: In control and experimental groups mean ages of participants were 34.66 ± (4.56) and 38.1 ± (4.90) respectively. In the experimental group from the result of significant change was observed (p < 0.05) in the variables between pre-tests and post-tests. Where significant change observed in experimental group, there was no significant change observed in control group.

Conclusion: The immune (CD4) cell counts of the subject under aerobic exercise were shown significant change after 12 weeks of aerobic exercise.


Keywords: CD4 Cell; Aerobic Exercise; ART


  1. UNAIDS, WHO. Report on the global AIDS EPIDEMIC (2011).
  2. “Country progress report on the HIV response”. The Federal Democratic Republic of Ethiopia (2014).
  3. JA Woods., et al. “Effects of 6 months moderate aerobic exercise training on immune function in the elderly”. Mechanisms of Ageing and Development Journal1 (1999): 1-19.
  4. HIV/AIDS in Ethiopia: Ethiopia Demographic and Health Survey (2011).
  5. Action IFOR. “Federal Democratic Republic of Ethiopia Ministry of Health Policy and practice 6.1 (2014).
  6. Dudgeon WD., et al. “Physiological and Psychological effects of exercise interventions in HIV disease”. AIDS Patient Care2 (2004): 81-98.
  7. Tiozzo E., et al. “Short-term combined exercise training improves the health of HIV-infected patients”. Journal of AIDS and Clinical Research 5 (2013): 80-89.
  8. O’Brien K., et al. “Effectiveness of aerobic exercise in adults living with HIV/AIDS”. Medicine and Science Sports and Exercise10 (2004): 1659-1666.
  9. Terry L., et al. “Exercise Training in HIV-1 Infected Individuals with Dyslipidemia and Lipodystrophy”. Medicine and Science in Sports Exercise 38 (2006): 411-417.
  10. Veljkovic V. “Can exercise help prevent and treat AIDS?” The Institute of Science in Society (ISIS) report (2005).
  11. Maduagwu SM., et al. “Effect of Aerobic Exercise on CD4 Cell Count and Lipid Profile of HIV Infected Persons in North Eastern Nigeria”. Journal of AIDS and Clinical Research 6 (2015): 508.
  12. Perna F., et al. “Cardiopulmonary and CD4 cell changes in response to exercise training in early symptomatic HIV infection”. Medicine and Science in Sports and Exercise 31 (1999): 973-979.
  13. Ramirez-marrero FA., et al. “Physical and leisure activity, body composition and lifestyle in HIV-positive Hispanics in Puerto Rico”. Journal of the Association of Nurses in AIDS Care4 (2004): 68-77.
  14. Shaheen HA. “The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men” (2012).
  15. Stringer WW. “HIV and aerobic exercise”. Sports Medicine6 (1999): 389-395.
  16. Smith CV. “The Mysterious Origin of Human Immunodeficiency Virus” (210).
  17. Joseph T. “The Benefits of Exercise Training for Quality of Life in HIV/AIDS in the Post-HAART Era”. Sports Medicine 8 (2004): 487-499.
  18. Baigis J., et al. “Effectiveness of a Home-Based Exercise Intervention For HIV-Infected Adults: A Randomized Trial”. Journal of the Association of Nurses in AIDS Care 13 (2002): 33-45.
  19. Bopp C. “Physical activity and immunity in HIV infected individuals”. University of Tennessee (2004).
  20. Ciccolo J., et al. “The benefits of exercise training for quality of life in HIV/AIDS in the post-HAART era”. Sports Medicine8 (2004): 487-499.
Citation: Girma Tilahun., et al. “Effect of Aerobic Exercise on CD4 Cell among People Living with HIV: Randomized Control Trial”. EC Orthopaedics 12.4 (2021): 22-27.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 20, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.