Research Article
Volume 12 Issue 3 - 2021
Influence of Polymorphic Options of the Vitamin D Receptor Gene on the Formation of Early of Osteoporotic Conditions with the Comorbidity of Osteoarthritis and Obesity in Persons of Young Age
Pasiyeshvili L1, Tereshkin K2* and Tereshkina O3
1Department of General Practice-Family Medicine and Internal Diseases, Kharkiv National Medical University, Kharkiv, Ukraine
2Department of Physical Rehabilitation and Sports Medicine, Kharkiv National Medical University, Kharkiv, Ukraine
3The First Medical Faculty, Kharkiv National Medical University, Kharkiv, Ukraine
*Corresponding Author: Tereshkin Kostyantyn, Assistant Professor of the Department of Physical Rehabilitation and Sports Medicine, Kharkiv National Medical University, Kharkov, Ukraine.
Received: January 21, 2021; Published: 00-00




Abstract

Objective of the Study: The objective of the work was to establish the prognostic and diagnostic importance of the G63980A polymorphism of the vitamin D receptor gene, the reference SNP (rs) 1544410 (VDR) in the cumulative course of osteoarthritis and obesity in young age people and to determine the possibility of predicting the risk of developing bone mineral density in these patients.

Materials and Methods: 96 young age patients (35.5 ± 0.9) with comorbid OA and obesity and 96 practically healthy individuals identical in age and sex were examined. The control group consisted of 18 people with osteoarthritis and normal weight. Anthropometric criterion of obesity was considered the Quetelet index. The assessment of the functional state of the musculoskeletal system and the analysis of indicators of algo-functional activity were determined using the WOMAC test questionnaire. Measurements of bone mineral density were performed using dual energy X-ray absorptiometry (DEXA) on a HOLOGIC Explorer QDR W Series Bone Densitometer (USA). Gene polymorphism was investigated in the human genome by real-time polymerase chain reaction using the VDR kit (Bsml c. IVS7 G> A, rs1544410) “Vitamin D receptor mutation”. Statistical data analysis was performed using the Stata 12.1 software package: statistical processing - using the W-criterion Shapiro-Wilkie, Pearson and the homogeneity of the dispersions - Leven criterion. The indicator of the relative risk of developing the disease, the odds ratio (OR) was calculated using the mathematical formula: OR = (Pr (c | A) / Pr (nc | A)) / (Pr (c | C)/Pr (nc | C)).

Results: It was established that, despite the short anamnesis of the disease, the course of osteoarthritis with obesity is accompanied by a prevalence of severe radiographic forms of joint damage (40.6%) versus 16.7% in the comparison group. The analysis of the frequency and nature of absorptiometrically verified disorders of the bone mineral density showed that in 59.4% of the patients of the main group osteopenic states developed. In patients of the comparison group, abnormalities of the BMD were observed in 50% of patients.

Conclusion: The presence of obesity in young age people with osteoarthritis worsens the clinical and instrumental manifestations of the disease, as evidenced by the predominance of more severe radiological stages of the disease and an increase in the indicators of the algo-functional index WOMAC. Despite the short anamnesis of the disease, with comorbidity of osteoarthritis and obesity in young age people, there are prerequisites for the formation of osteopenic complications. Among patients with osteoarthritis and obesity an unfavorable BB variant of the vitamin D receptor gene genotype is found more often compared with the control group, which is confirmed by pronounced X-ray progression of joint damage. The adverse effect of the B-allele of the VDR gene on the course of OA in patients with obesity is confirmed by the presence of impaired bone mineral density. It was also established that the variant of bb polymorphism of the VDR gene in patients with OA and obesity is most favorable for the course of the disease.

 

Keywords: Osteoarthritis; Obesity; Vitamin D Receptor Gene; Osteoporosis

References

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Citation: Tereshkin K., et al. “Influence of Polymorphic Options of the Vitamin D Receptor Gene on the Formation of Early of Osteoporotic Conditions with the Comorbidity of Osteoarthritis and Obesity in Persons of Young Age”. EC Orthopaedics 12.3 (2021): 55-61.

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