Research Article
Volume 12 Issue 2 - 2021
The Efficacy and Safety of 2-Year Treatment with Zoledronic Acid in Patients with Osteoporosis and the Influence of Previous Treatments in Actual Clinical Practice
Fumitoshi Omura*
Koenji Orthopedics Clinic, Tokyo, Japan
*Corresponding Author: Fumitoshi Omura, Koenji Orthopedics Clinic, Tokyo, Japan.
Received: December 17, 2020; Published: January 18, 2021


Purpose: To investigate the efficacy and safety of treatment with zoledronic acid (ZOL).

Methods: Retrospective analyses were performed on patients with primary osteoporosis who received ZOL for 24 months. I analyzed some indicators, including changes in BMD (bone mineral density) until 24 months after the start of ZOL administration. Moreover, according to treatments prior to the administration of ZOL, patients were divided into 3 groups and all groups were analyzed. Patients who received ZOL after 18-month administration of 56.5-μg teriparatide formulation for once-weekly use (1/W-TPTD) were also analyzed.

Results: In 41 patients whose data were collected until 24 months after the start of ZOL administration, the lumbar spine BMD was significantly increased from baseline by 5.2% (3.6% - 6.9%) at 6 months after the start of ZOL administration, 6.8% (5.1% - 8.6%) at 12 months, 9.1% (7.3% - 11.0%) at 18 months, and 10.0% (8.1% - 11.9%) at 24 months. The femoral neck BMD was also significantly improved. Regarding previous treatments, the lumbar spine BMD and the femoral neck BMD was maintained/increased in each of 3 groups. In a group of patients who received ZOL after receiving treatment with 1/W-TPTD, ZOL administration significantly increased BMD further. A significant improvement was also observed in visual analog scale score of back pain, total Japanese Osteoporosis Quality of Life Questionnaire (JOQOL) score, and some individual JOQOL scores.

Conclusion: ZOL, which only needs to be administered once a year and has good compliance, can be a useful option for the treatment of osteoporosis.

Keywords: Zoledronic Acid; Teriparatide; Osteoporosis; Bone Mineral Density; Born Turnover Marker


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Citation: Fumitoshi Omura. “The Efficacy and Safety of 2-Year Treatment with Zoledronic Acid in Patients with Osteoporosis and the Influence of Previous Treatments in Actual Clinical Practice”.EC Orthopaedics 12.2 (2021): 73-86.

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