Volume 12 Issue 1 - 2021
Utilization of Different Osteogenic Cells in Cell Therapy in Bone Healing
A Oryan and S Sahvieh
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
*Corresponding Author: A Oryan, Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Received: November 17, 2020; Published: December 28, 2020

The main concern of the researchers and orthopedic surgeons is to find an efficient method for bone healing. Because of some conditions such as accidents, trauma, burns, non-union bone defects, myeloma-related bone diseases, osteotomies, arthritis, bone tumor resections, osteomyelitis, pathologic fractures, osteoporosis, chronic bone infections, osteoarthritis, and bone cancer which cause extensive bone defects, bone tissue regeneration and reconstruction is notable. In addition to impact the quality of life and health of the patients, the multibillion-dollar cost of bone fractures is also significant [1-4].


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  2. Oryan A., et al. “Effects of osteogenic medium on healing of the experimental critical bone defect in a rabbit model”. Bone 63 (2014): 53-60.
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  6. Kyllonen L., et al. “Local drug delivery for enhancing fracture healing in osteoporotic bone”. Acta Biomaterialia 11 (2015): 412-434.
  7. Oryan A., et al. “Effectiveness of mesenchymal stem cell-seeded onto the 3D polylactic acid/polycaprolactone/hydroxyapatite scaffold on the radius bone defect in rat”. Life Sciences 257 (2020): 118038. doi: 10.1016/j.lfs.2020.118038.
  8. Oryan A., et al. “Bone Injury and Fracture Healing Biology”. Biomedical and Environmental Sciences 28 (2015): 57-71.
  9. Oryan A and Sahvieh S. “Effectiveness of chitosan scaffold in skin, bone and cartilage healing”. International Journal of Biological Macromolecules 104 (2017): 1003-1011.
  10. Oryan A and Moshiri A. “A long term study on the role of exogenous human recombinant basic fibroblast growth factor on the superficial digital flexor tendon healing in rabbits”. Journal of Musculoskeletal and Neuronal Interactions 11 (2011): 185-195.
  11. Oryan A., et al. “Effectiveness of tissue engineered chitosan-gelatin composite scaffold loaded with human platelet gel in regeneration of critical sized radial bone defect in rat”. Journal of Controlled Release 254 (2017): 65-77.
  12. Moshiri A., et al. “Role of tissue-engineered artificial tendon in healing of a large achilles tendon defect model in rabbits”. Journal of American Collage Surgeons 217 (2013): 421-441.
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  16. Oryan A., et al. “Chemical crosslinking of biopolymeric scaffolds: current knowledge and future directions of crosslinked engineered bone scaffolds” International Journal of Biological Macromolecules 107 (2017): 678-688.
  17. Malgieri A., et al. “Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art”. International Journal of Clinical and Experimental Medicine 3 (2010): 248-269.
  18. Jager M., et al. “Bone Healing and Migration of Cord Blood-Derived Stem Cells Into a Critical Size Femoral Defect After Xenotransplantation”. Journal of Bone and Mineral Research 22 (2007): 1224-1233.
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  20. Baghaban-Eslaminejad M., et al. “Type I collagen gel in seeding medium improves murine mesencymal stem cell loading onto the scaffold, increases their subsequent proliferation, and enhances culture mineralization”. Journal of Biomedical Materials Research B Appllied Biomaterial 90 (2009): 659-667.
  21. Oryan A., et al. “Synergistic effect of strontium, bioactive glass and nano-hydroxyapatite promotes bone regeneration of critical-sized radial bone defects”. Journal of Biomedical Materials Research Part B 107 (2018): 50-64.
  22. Tortelli F., et al. “The development of tissue engineered bone of different origin through endochondral and intramembranous ossification following the implantation of mesenchymal stem cells and osteoblasts in a murine model”. Biomaterials 31 (2010): 242-249.
  23. Fu X., et al. “Mesenchymal stem cell migration and tissue repair”. Cells 8 (2019): 784-800.
  24. Luo CH., et al. “Biomimetic open porous structured core-shell microtissue with enhanced mechanical properties for bottom-up bone tissue engineering”. Theranostics 9 (2019): 4663-4677.
  25. Weiab JQ., et al. “Enhanced critical-sized bone defect repair efficiency by combining deproteinized antler cancellous bone and autologous BMSCs”. Chinese Chemical Letters 28 (2017): 845-850.
  26. Tsai TL and Li WJ. “Identification of bone marrow-derived soluble factors regulating human mesenchymal stem cells for bone regeneration”. Stem Cell Reports Journal 8 (2017): 387-400.
  27. Zhang Y., et al. “Injectable hydrogels from enzyme-catalyzed crosslinking as BMSCs-laden scaffold for bone repair and regeneration”. Materials Science and Engineering C 96 (2019): 841-849.
  28. Oryan A., et al. “Role of mesenchymal stem cells in bone regenerative medicine: What is the evidence?” Cells Tissues Organs 204 (2017): 59-83.
  29. Sahvieh S., et al. “Role of bone 1stem cell-seeded 3D polylactic acid/polycaprolactone/hydroxyapatite scaffold on a critical-sized radial bone defect in rat”. Cell and Tissue Research (2020): 32924069. doi: 10.1007/s00441-020-03284-9.
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  31. Liuac Y., et al. “Integration of a calcined bovine bone and BMSC-sheet 3D scaffold and the promotion of bone regeneration in large defects”. Biomaterials 34 (2013): 9998-10006.
  32. Rosset P., et al. “Cell therapy for bone repair”. Orthopaedics and Traumatology: Surgery and Research 100 (2014): S107-S112.
Citation: A Oryan and S Sahvieh. “Utilization of Different Osteogenic Cells in Cell Therapy in Bone Healing”.EC Orthopaedics 12.1 (2021): 01-04.

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