Research Article
Volume 11 Issue 12 - 2020
Magnesium and Hip Fractures: An Overlooked Macro Mineral?
Ray Marks*
Department of Health and Behavior Studies, Teachers College, Columbia University, New York, United States
*Corresponding Author: Ray Marks, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, United States.
Received: November 04, 2020; Published: November 25, 2020


Introduction: Hip fractures, which remain highly prevalent oftentimes life-threatening events among older populations, are highly challenging to prevent and treat effectively despite years of multiple related endeavors.

Objectives: This mini-review strove to examine whether: 1) magnesium, an important dietary compound is a relatively unrecognized, and hence underutilized potentially important hip fracture determinant among the older at risk adult, and 2) whether more research and consideration of its nutrient properties in this realm is warranted.

Methods: Relevant data concerning this topic sought from three well-established preselected electronic data bases housing English language research or commentary reports published over the last 40 years (1980 - 2020) were carefully examined. Reviewed specifically were representative recent studies and reviews, including their conclusions regarding the possible relevance of efforts to assess and treat magnesium deficits in the context of hip fracture prevention among the elderly.

Results: Despite quite compelling basic research showing a high number of magnesium-dependent health interactions that impact well-being across the lifespan, including bone health, very few explicit or targeted studies on the present topic were located. However, among those located, most if not all, point to a potentially important clinically relevant association between magnesium and hip fractures.

Conclusion: More intense and thoughtfully designed research to examine the multiple ways magnesium may mediate hip fracture risk and recovery, both of which remain largely impervious to current approaches, appears to have untapped potential for reducing the persistent global age-associated hip fracture burden and its immense associated human and social costs.

Keywords: Bone Health; Fractures; Hip Fractures; Intervention; Magnesium; Prevention; Supplementation


  1. Emmerson BR., et al. “Hip fracture overview”. In: Stat Pearls [Internet]. Treasure Island (FL): Stat Pearls Publishing (2020).
  2. Orchard TS., et al. “Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study”. American Journal of Clinical Nutrition4 (2014): 926-33.
  3. Hirota T., et al. “Present knowledge in nutritional aspects of fracture”. Clinical Calcium12 (2006): 2017-2025.
  4. Van Dronkelaar C., et al. “Minerals and sarcopenia; the role of calcium, iron, magnesium, phosphorus,potassium, selenium, sodium, and zinc on muscle mass, muscle strength, and physical performance in older adults: a systematic review”. Journal of the American Medical Directors Association1 (2018): 6-11.e3.
  5. Veronese N., et al. “Effect of oral magnesium supplementation on physical performance in healthy elderly women involved in a weekly exercise program: a randomized controlled trial”. American Journal of Clinical Nutrition3 (2014): 974-981.
  6. Genuis SJ., and Bouchard TP. “Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention”. Journal of Environmental Public Health (2012): 354151.
  7. Farsinejad-Marj M., et al. “Dietary magnesium intake, bone mineral density and risk of fracture: a systematic review and meta-analysis”. Osteoporosis International4 (2016): 1389-1399.
  8. Hayhoe RP., et al. “Dietary magnesium and potassium intakes and circulating magnesium are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the EPIC-Norfolk cohort study”. American Journal of Clinical Nutrition2 (2015): 376-384.
  9. Groenendijk I., et al. “Hip fracture patients in geriatric rehabilitation show poor nutritional status, dietary intake and muscle health”. Nutrients12 (2020): 2528.
  10. Brodziak-Dopierała B., et al. “Distribution of magnesium, calcium, sodium and potassium in tissues of the hip joint”. Magnesium Research3 (2013): 125-131.
  11. Dahl C., et al. “Nationwide data on municipal drinking water and hip fracture: could calcium and magnesium be protective? A NOREPOS study”. Bone 1 (2013): 84-91.
  12. Karaaslan F., et al. “Comparison of bone tissue trace-element concentrations and mineral density in osteoporotic femoral neck fractures and osteoarthritis”. Clinical Interventions in Aging 9 (2014): 1375-1382.
  13. Kunutsor SK., et al. “Low serum magnesium levels are associated with increased risk of fractures: a long-term prospective cohort study”. European Journal of Epidemiology 7 (2017): 593-603.
  14. Uwitonze AM., and Razzaque MS. “Role of magnesium in vitamin D activation and function”. Journal of the American Osteopathic Association 3 (2018): 181-189.
  15. Welch AA., et al. “Dietary magnesium may be protective for aging of bone and skeletal muscle in middle and younger older age men and women: cross-sectional findings from the UK Biobank Cohort”. Nutrients11 (2017): 1189.
  16. Acosta-Olivo C., et al. “Infiltración intraarticular con sulfato de magnesio y bupivacaína en fracturas de radio distal. Estudio piloto [Intrarticular infiltration of bupivacaine and magnesium sulfate in distal radius fractures”. A pilot study]”. Acta Ortopedica Mexicano 2017 5 (2017): 217-221.
  17. Capozzi A., et al. “Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health”. Maturitas 140 (2020): 55-63.
  18. Erem S., et al. “Anabolic effects of vitamin D and magnesium in aging bone”. Journal of Steroid Biochemistry and Molecular Biology 193 (2019) :105400.
  19. Barbagallo M, and Dominguez LJ. “Magnesium and aging”. Current Pharmaceutical Drugs7 (2010): 832-839.
  20. Zullo AR., et al. “Predictors of hip fracture despite treatment with bisphosphonates among frail older adults”. Journal of the American Geriatric Society2 (2020): 256-260.
  21. Malmir H., et al. “Consumption of milk and dairy products and risk of osteoporosis and hip fracture: a systematic review and meta-analysis”. Critical Reviews in Food Science and Nutrition10 (2020): 1722-1737.
  22. Goggs R., et al. “Nutraceutical therapies for degenerative joint diseases: a critical review”. Critical Reviews in Food Science and Nutrition3 (2005): 145-164.
  23. Tucker KL., et al. “Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women”. American Journal of Clinical Nutrition4 (1999): 727-736.
  24. Reddy P and Edwards LR. “Magnesium supplementation in vitamin D deficiency”. American Journal of Therapeutics1 (2019): e124-e132.
  25. Michaëlsson K., et al. “Diet and hip fracture risk: a case-control study. Study Group of the Multiple Risk Survey on Swedish Women for Eating Assessment”. International Journal of Epidemiology4 (1995): 771-782.
  26. Wu YY., et al. “Magnesium oxide and hip fracture in the elderly: a population-based retrospective cohort analysis”. Osteoporosis International7 (2020): 1231-1238.
  27. Milachowski K., et al. “Die bedeutung von magnesium, kupfer und zink bei der medialen schenkelhalsfraktur des alten menschen [Significance of magnesium, copper and zinc in medial femur neck fractures in the aged]”. Zeitschrift fur Gerontology6 (1980): 524-529.
  28. Nieves JW. “Calcium, vitamin D, and nutrition in elderly adults”. Clinics in Geriatric Medicine2 (2003): 321-335.
  29. Castiglioni S., et al. “Magnesium and osteoporosis: current state of knowledge and future research directions”. Nutrients 5 (2013): 3022-3033.
  30. Singh VK., et al. “Simultaneous, bilateral pathological displaced intracapsular hip fractures occurring spontaneously secondary to osteomalacia of hypomagnesemic origin: a case report and review of the literature”. European Journal of Trauma and Emergency Surgery1 (2009): 81.
  31. Mongiorgi R., et al. “Bone mineral alterations and Mg content in aging”. Bolletino della Societa Italiano dl Biologia Sperimentale7 (1990): 623-630.
  32. Kayalha H., et al. “Effect of intervenous magnesium sulfate on decreasing opioid requirement after surgery of the lower limb fracture by spinal anesthesia”. International Journal of Preventive Medicine 10 (2019): 57.
  33. Michaelsson K., et al. “Effect of prefracture versus postfracture dietary assessment on hip fracture risk estimates”. International Journal of Epidemiology2 (1996): 403-410.
  34. Kirkland AE., et al. “The role of magnesium in neurological disorders”. Nutrients6 (2018): 730.
  35. Gröber U., et al. “Magnesium in prevention and therapy”. Nutrients9 (2015): 8199-8226.
  36. Yaegashi Y., et al. “Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K”. European Journal of Epidemiology3 (2008): 219-225.
  37. No authors listed. “Taking magnesium could prevent bone fractures in middle age”. Nursing Standard 2017 31.37 (2017): 17.
  38. Sojka JE., and Weaver CM. “Magnesium supplementation and osteoporosis”. Nutrition Review3 (1995): 71-74.
  39. Welch AA., et al. “Dietary magnesium is positively associated with skeletal muscle power and indices of muscle mass and may attenuate the association between circulating c-reactive protein and muscle mass in women”. Journal of Bone and Mineral Research2 (2016): 317-325.
  40. Guerrera MP., et al. “Therapeutic uses of magnesium”. American Family Physician2 (2009): 157-162.
  41. Jahnen-Dechent W and Ketteler M. “Magnesium basics”. Clinical Kidney JournalS1 (2012): i3-i14.
  42. Pepa GD and Brandi ML. “Microelements for bone boost: the last but not the least”. Clinical Cases in Mineral and Bone Metabolism3 (2016): 181-185.
  43. Rude RK., et al. “Skeletal and hormonal effects of magnesium deficiency”. Journal of the American College of Nutrition2 (2009): 131-141.
  44. Toba Y., et al. “Dietary magnesium supplementation affects bone metabolism and dynamic strength of bone in ovariectomized rats”. Journal of Nutrition2 (2000): 216-220.
  45. Tucker KL., et al. “Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women”. American Journal of Clinical Nutrition4 (1999): 727-736.
Citation: Ray Marks. “Magnesium and Hip Fractures: An Overlooked Macro Mineral?”. EC Orthopaedics 11.12 (2020): 01-09.

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