Mini Review
Volume 11 Issue 10 - 2020
The Application of NOLFs and Variegated Fullerene Materials in Orthopedic Diseases and Disorders
Nicholas A Kerna1* and John V Flores2,3
1SMC–Medical Research, Thailand
2Beverly Hills Wellness Surgical Institute, USA
3Orange Partners Surgicenter, USA
*Corresponding Author: Nicholas A Kerna, POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: August 14, 2020; Published: September 30, 2020


Since the 1980s, carbon fullerene materials have been investigated for medical applications in humans. Nanocarbon onion-like fullerenes (NOLFs) and variegated fullerene materials are composed of carbon atoms and compatible with the human body. They reduce free radicals in cells, provide anti-inflammatory effects, and inhibit tumor growth. The primary antioxidant benefit of fullerene materials might be through the activation of Nrf2. Fullerene materials are utilized in molecular scaffolds, aiding bone reformation and repair and supporting the growth, proliferation, osteogenetic differentiation, and differentiation of bone-derived stem cells. Fullerene materials improve the outcomes and shorten the recovery time in joint replacement and orthopedic bone cement procedures. Although fullerene materials have demonstrated beneficial applications in a variety of bone, muscle, and cartilage conditions, their manufacture, dosage, timing, and duration should be further evaluated and established for therapeutic use in specific conditions by evidence-based research.

Keywords: Biocompatibility; Bone Tissue Engineering; Graphitization; Nanocarbon; Osteoporosis; Scaffold


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Citation: Nicholas A Kerna and John V Flores. “The Application of NOLFs and Variegated Fullerene Materials in Orthopedic Diseases and Disorders”. EC Orthopaedics 11.10 (2020): 78-82.

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