Case Report
Volume 11 Issue 10 - 2020
Diagnostic Value of Antibodies with Inflammatory Markers, RDW and MPV in Rheumatoid Arthritis Patients
Reyhaneh Tabarrai1,2, Saeed Shakiba3, Shokoufeh Mousavi1,2 and Maryam Masoumi1,2*
1Department of Internal Medicine, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
2Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran
3School of medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Maryam Masoumi, Department of Internal Medicine, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Received: August 03, 2020; Published: September 28, 2020




Abstract

Background: The aim of the study was to assess relationship between the Red cell distribution width (RDW), mean platelet volume (MPV), rheumatoid arthritis (RA) autoantibodies against modified citrullinated vimentin antibodies (anti-MCV) and anticyclic citrullinated peptide antibodies (anti-CCP) in comparison to the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in RA.

Methods: 200 patients with RA were enrolled. We used the Disease Activity Score of 28 joints (DAS28) instrument to evaluate disease activity. Laboratory assessments included complete blood cell counts, ESR and assessment of CRP level, anti-CCP, anti-MCV and rheumatoid arthritis (RF).

Results: We found that RDW and MPV varied by disease activity status. RDW values correlated positively with the DAS28 scores of RA patients. Especially, higher RDW values (16.37 (S.D. 1.80), P < 0.001) were evident in the baseline, whereas the MPV values were lowest (6.06 (S.D. 1.66), P < 0.001) in this time.

Conclusion: Anti-MCV and anti-CCP were useful tools in the diagnosis of RA in early stages. RF, anti-CCP and anti-MCV antibodies can be considered along with ESR and CRP for monitoring RA patients to assess disease activity. We suggest that the MPV value can be used as negative phase reactant disease, whereas RDW is a positive marker.

Keywords: Red Cell Distribution Width; Mean Platelet Volume; Rheumatoid Arthritis; Anti-Inflammatory Marker

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Citation: Maryam Masoumi., et al. “Diagnostic Value of Antibodies with Inflammatory Markers, RDW and MPV in Rheumatoid Arthritis Patients”. EC Orthopaedics 11.10 (2020): 23-31.

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