Research Article
Volume 11 Issue 7 - 2020
Evaluation of Allopurinol (Xanthine Oxidase Inhibitor) in Management of Primary Gout (Niqras)
Hila Akhtarl1*, Misbahuddin Siddiqi2, Mohammad Saad Ahmad Khan3 and Syed Zeba Husain4
1Assistant Professor, Department of Amraz-e-Jild Wa Tazeeniyaat, AIUMC and Hospital, Muzaffarnagar, Uttar Pradesh, India
2Professor, Department of Moalijat, Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
3Assistant Professor, Department of Ilaj-bit-Tadbeer, Faculty of Unani Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
4Private Unani Practitioner, Aligarh, Uttar Pradesh, India
*Corresponding Author: Hilal Akhtar, Assistant Professor, Department of Amraz-e-Jild Wa Tazeeniyaat, AIUMC and Hospital, Muzaffarnagar, Uttar Pradesh, India.
Received: May 16, 2020; Published: June 20, 2020


Gout is the most prevalent crystals-induce arthropathy and is associated with impaired health-related quality of life. It is characterized by hyperuricemia and recurrent attacks of acute arthritis, often eventually associated with urate deposits in the tissues which may be manifest as tophi. Several studies suggest that its prevalence and incidence have risen in recent decades. The objective of present trial was to validate and to assess the efficacy and safety of Xanthine-oxidase inhibitor drug- Allopurinol on the patients of primary gout. The study was of 18 months and designed as a randomized open-label with a sample size of 30 patients. The progress in subjective parameters was evaluated weekly, and at the baseline, fifteen days and thirty days in objective parameter. On the basis of severity, the subjective parameters were ranked arbitrarily from 0- 3. There was observed a considerable improvement in subjective as well as objective parameters and no undesirable effect during and at the end of trial. Therefore, it can be deduced that Allopurinol was considerably capable in resolving the signs and symptoms of primary gouty patients and significantly reduced the serum urate level.

Keywords: Arthropathy; Allopurinol; Gout; Hyperuricemia; Niqras; Urate


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Citation: Hilal Akhtar., et al. “Evaluation of Allopurinol (Xanthine Oxidase Inhibitor) in Management of Primary Gout (Niqras)”. EC Orthopaedics 11.7 (2020): 61-72.

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