Mini Review
Volume 11 Issue 7 - 2020
The Good, the Bad and the Ugly of Stromal Cell-Derived Factor 1a in Musculoskeletal Disorders
Dingqi Xie1, Ximiao Yu1, Yuhan Bao1, Yiyao Ding1, Miao Li2, Quanming Wang3 and Lei Ding1*
1Jiangnan University Wuxi College of Medicine, Wuxi, Jiangsu, China
2Jiangnan University School of Humanities, Wuxi, Jiangsu, China
3Department of Orthopaedic Surgery, Jiangnan University Affiliated Hospital, Wuxi, Jiangsu, China
*Corresponding Author: Lei Ding, Associate Professor, Jiangnan University Wuxi College of Medicine, Wuxi, Jiangsu, China.
Received: May 08, 2020; Published: June 02, 2020


Stromal cell-derived factor 1a (SDF-1a), alternatively named as CXCL12, is a chemokine playing multi-faceted roles in musculoskeletal disorders. It could attract chondrogenic progenitor cells to cartilage lesions, which would promotes the repair of tissue injury resulted from mechanical insults. On the other hand, it acted as an inflammatory mediator that could exacerbate the pathological conditions of osteoarthritis and rheumatoid arthritis. Even worse, SDF-1a could act through its specific membrane receptor CXCR4 to facilitate the progression and bone metastasis of some malignant tumors. In this review, we focus on the research progress in the past decade examining the double-edged effect of this unique chemokine on common musculoskeletal disorders, including joint injury, arthritis, and tumor bone metastasis.

Keywords: SDF-1a; CXCR4; Cartilage Repair; Arthritis; Bone Metastasis


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Citation: Dingqi Xie., et al. “The Good, the Bad and the Ugly of Stromal Cell-Derived Factor 1a in Musculoskeletal Disorders”. EC Orthopaedics 11.7 (2020): 01-04.

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