Short Communication
Volume 11 Issue 7 - 2020
Smart Biomaterials and Systems for Bone Tissue Engineering
Esmat Alemzadeh1,2 and Ahmad Oryan3*
1Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
2Department of Medical Biotechnology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
3Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
*Corresponding Author: Ahmad Oryan, Professor of Comparative Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Received: March 20, 2020; Published: June 03, 2020




Bone is a part of the skeletal system and supports body shape and its movement [1]. Bone fracture generally occurs because of traumas, specific bone diseases, high force impact or stress. This clinical problem can finally lead to instability and poor alignment of the body structures and depression [2]. Although autografts are the common method of tissue replacement, some disadvantages such as pain at the donor site have limited their application. On the other hand, several disadvantages such as disease transmission, low viability of the grafts are the most significant limitations of the allografts and xenografts [1,3]. Bone tissue engineering (BTE) as an emerging field focuses on alternative treatment options that will overcome many limitations of the current treatments (i.e. additional surgery, disease transmission, immune rejection, and limited availability) [4,5].

References

  1. Oryan A., et al. “Bone regenerative medicine: classic options, novel strategies, and future directions”. Journal of Orthopaedic Surgery and Research1 (2014): 18.
  2. Oryan A., et al. “Bone injury and fracture healing biology”. Biomedical and Environmental Sciences1 (2015): 57-71.
  3. Oryan A., et al. “Role of mesenchymal stem cells in bone regenerative medicine: what is the evidence?” Cells Tissues Organs2 (2017): 59-83.
  4. Amini AR., et al. “Bone Tissue Engineering: Recent Advances and Challenges”. Critical Reviews in Biomedical Engineering5 (2012): 363-408.
  5. Oryan A., et al. “Current concerns regarding healing of bone defects”. Hard Tissue2 (2013): 13.
  6. Murphy CM., et al. “Cell-scaffold interactions in the bone tissue engineering triad”. European Cells and Materials 26 (2013): 120-132.
  7. Oryan A., et al. “Potential mechanisms and applications of statins on osteogenesis: Current modalities, conflicts and future directions”. Journal of Controlled Release 215 (2015): 12-24.
  8. De Witte TM., et al. “Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices”. Regenerative Biomaterials4 (2018): 197-211.
  9. Bagde AE., et al. “State of the art technology for bone tissue engineering and drug delivery”. IRBM3 (2019): 133-144.
  10. Bigham-Sadegh A and Oryan A. “Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures”. International Wound Journal3 (2015): 238-247.
  11. Balmayor ER., et al. “Controlled delivery systems: from pharmaceuticals to cells and genes”. Pharmaceutical Research6 (2011): 1241-1258.
  12. Dhanasekaran S and Chopra S. “Getting a handle on smart drug delivery systems - a comprehensive view of therapeutic targeting strategies”. Smart Drug Delivery System. InTech (2016).
  13. Kelley EG., et al. “Stimuli-responsive copolymer solution and surface assemblies for biomedical applications”. Chemical Society Reviews17 (2013).
  14. Mura S., et al. “Stimuli-responsive nanocarriers for drug delivery”. Nature Materials11 (2013): 991-1003.
  15. Wang C., et al. “Improving bone regeneration using Chordin siRNA delivered by pH-responsive and non-toxic polyspermine imidazole-4,5-imine”. Cellular Physiology and Biochemistry1 (2018): 133-147.
  16. Gan Q., et al. “A dual-delivery system of pH-responsive chitosan-functionalized mesoporous silica nanoparticles bearing BMP-2 and dexamethasone for enhanced bone regeneration”. Journal of Materials Chemistry B 10 (2015): 2056-2066.
  17. Motamedian SR., et al. “Smart scaffolds in bone tissue engineering: A systematic review of literature”. World Journal of Stem Cell 3 (2015): 657-668.
  18. Moshiri A., et al. “Role of Simvastatin on fracture healing and osteoporosis: a systematic review on in vivo investigations”. Clinical and Experimental Pharmacology and Physiology7 (2016): 659-684.
  19. Zhang K., et al. “Advanced smart biomaterials and constructs for hard tissue engineering and regeneration”. Bone Research 6 (2018): 31.
  20. Kaigler D., et al. “VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects”. Journal of Bone and Mineral Research5 (2006): 734-744.
  21. Murphy WL., et al. “Materials as stem cell regulators”. Nature Materials6 (2014): 547-557.
  22. Kamali A., et al. “Cannabidiol-loaded microspheres incorporated into osteoconductive scaffold enhance mesenchymal stem cell recruitment and regeneration of critical-sized bone defects”. Materials Science and Engineering: C 101 (2019): 64-75.
  23. Crupi A., et al. “Inflammation in tissue engineering: The Janus between engraftment and rejection”. European Journal of Immunology12 (2015): 3222-3236.
  24. Andorko JI and Jewell CM. “Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine”. Bioengineering and Translational Medicine2 (2017): 139-155.
  25. Sokolowska M., et al. “Low molecular weight hyaluronan activates cytosolic phospholipase A2α and eicosanoid production in monocytes and macrophages”. Journal of Biological Chemistry7 (2014): 4470-4488.
  26. Tiller JC., et al. “Improving biomaterial properties of collagen films by chemical modification”. Biotechnology and Bioengineering 3 (2001): 246-252.
  27. Zakeri Siavashani A., et al. “Silk based scaffolds with immunomodulatory capacity: anti-inflammatory effects of nicotinic acid”. Biomaterials Science1 (2020): 148-162.
  28. Bai L., et al. “A multifaceted coating on titanium dictates osteoimmunomodulation and osteo/angio-genesis towards ameliorative osseointegration”. Biomaterials 162 (2018): 154-169.
  29. Ahadian S and Khademhosseini A. “Smart scaffolds in tissue regeneration”. Regenerative Biomaterials3 (2018): 125-128.
  30. Khan F and Tanaka M. “Designing smart biomaterials for tissue engineering”. International Journal of Molecular Sciences1 (2017): E17.
  31. Wang L., et al. “Smart, Elastic, and nanofiber-based 3D scaffolds with self-deploying capability for osteoporotic bone regeneration”. Nano Letters12 (2019): 9112-9120.
Citation: Esmat Alemzadeh and Ahmad Oryan. “Smart Biomaterials and Systems for Bone Tissue Engineering”. EC Orthopaedics 11.7 (2020): 01-04.

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