Research Article
Volume 11 Issue 5 - 2020
Vitamin C and Hip Fractures-Review
Ray Marks*
Department of Health and Behavior Studies, Teachers College, Columbia University, NY, United States
*Corresponding Author: Marks Ray, Department of Health and Behavior Studies, Teachers College, Columbia University, New York, NY, United States.
Received: April 08, 2020; Published: April 20, 2020




Abstract

Introduction: Disabling or life-threatening hip fractures, which are highly prevalent among older populations remain highly challenging to prevent and treat effectively.

Objectives: This mini-review strove to examine whether: 1) vitamin C, a powerful antioxidant potentially involved in many physiological processes, such as bone maintenance, may possibly influence the risk of hip fracture and/or reduce its adverse consequences, and 2) more research in this realm is warranted and should be undertaken.

Methods: A comprehensive scan and narrative review of available relevant English language research reports published over the last 40 years (1980 - 2020) and located in key data bases was undertaken. Reviewed specifically were the selected study conclusions, approaches, sampling methods, study sample, and hip fracture vitamin C associations.

Results: Along with very few studies on the present topic, no clear conclusion as regards the nature of any clinically relevant association between vitamin C and hip fractures was evidenced among the diverse published works. More recent works are however, alluding to more favorable mediating or moderating effects on hip fracture injuries than not, especially in the context of prevailing vitamin C deficiencies.

Conclusion: More research to delineate a possible clinically important mediating role for vitamin C in the context of hip fractures, which remain largely impervious to current modes of prevention and long-term intervention is strongly indicated to advance this potential area of salience for reducing the hip fracture burden.

Keywords: Ascorbic Acid; Bone Health; Hip Fractures; Intervention; Prevention; Surgery; Vitamin C

References

  1. Dizdarevic A., et al. “A comprehensive review of analgesia and pain modalities in hip fracture pathogenesis”. Current Pain Headache Reports 10 (2019): 72.
  2. Chin KY. and Ima-Nirwana S. “Vitamin C and bone health: evidence from cell, animal and human studies”. Current Drug Targets5 (2018): 439-450.
  3. Aghajanian P., et al. “The roles and mechanisms of actions of vitamin C in bone: new developments”. Journal of Bone and Mineral Research11 (2015): 1945-1955.
  4. Hill-Mündel K., et al. “Preoperative ascorbic acid levels in proximal femur fracture patients have no postoperative clinical impact, while ascorbic acid levels upon discharge have a major effect on postoperative outcome”. Journal of Clinical Medicine1 (2019): E66.
  5. Veronese N and Maggi S. “Epidemiology and social costs of hip fracture”. Injury8 (2018):1458-1460.
  6. Zheng LZ., et al. “Magnesium and vitamin C supplementation attenuates steroid-associated osteonecrosis in arat model”. Biomaterials 238 (2020): 119828.
  7. Lykkesfeldt J., et al. “Vitamin C”. Advances in Nutrition1 (2014):16-18.
  8. Takisawa S., et al. “Vitamin C deficiency causes muscle atrophy and a deterioration in physical performance”. Science Reports1 (2019): 4702.
  9. Guo YE., et al. “Vitamin C promotes oligodendrocytes generation and remyelination”. Glia7 (2018): 1302- 1316.
  10. Ripani U., et al. “Vitamin C may help to reduce the knee's arthritic symptoms. Outcomes assessment of nutriceutical therapy”. Medical Archives3 (2019): 173-177.
  11. Shaik-Dasthagirisaheb YB., et al. “Role of vitamins D, E and C in immunity and inflammation”. Journal of Biological Regulatory Homeostatic Agents2 (2013): 291-295.
  12. Savini I., et al. “Vitamin C homeostasis in skeletal muscle cells”. Free Radical Biology Medicine7 (2005): 898-907.
  13. Finck H., et al. “Cross-sectional and prospective associations between dietary and plasma vitamin C, heel bone ultrasound, and fracture risk in men and women in the European Prospective Investigation into Cancer in Norfolk cohort”. American Journal of Clinical Nutrition6 (2015): 1416-1424.
  14. Hart A., et al. “The role of vitamin C in orthopedic trauma and bone health”. American Journal of Orthopedics7 (2015): 306-311.
  15. Simon JA., and Hudes ES. “Relation of ascorbic acid to bone mineral density and self-reported fractures among US adults”. American Journal of Epidemiology5 (2001): 427-433.
  16. Pasco JA., et al. “Antioxidant vitamin supplements and markers of bone turnover in a community sample of nonsmoking women”. Journal of Womens’ Health3 (2006): 295-300.
  17. Falch JA., et al. “Low levels of serum ascorbic acid in elderly patients with hip fracture”. Scandinavian Journal of Clinical and Laboratory Investigation3 (1998): 225-228.
  18. Malmir H., et al. “Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies”. British Journal of Nutrition8 (2018): 847-858.
  19. Martínez-Ramírez MJ., et al. “Vitamin C, vitamin B12, folate and the risk of osteoporotic fractures. A case- control study”. International Journal of Vitamin Nutrition Research6 (2007): 359-368.
  20. Michaëlsson K., et al. “Diet and hip fracture risk: a case-control study. Study Group of the Multiple Risk Survey on Swedish Women for Eating Assessment”. International Journal of Epidemiology 4 (1995): 771- 782.
  21. Sahni S., et al. “Protective effect of total and supplemental vitamin C intake on the risk of hip fracture--a 17- year follow-up from the Framingham Osteoporosis Study”. Osteoporosis International 11 (2009): 1853-1861.
  22. Sun LL., et al. “Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study”. British Journal of Nutrition 10 (2014): 1706-1714.
  23. Orchard T., et al. “Dietary inflammatory index, bone mineral density, and risk of fracture in postmenopausal women: results from the Women's Health Initiative”. Journal of Bone and Mineral Research 5 (2017): 1136- 1146.
  24. Kim DE., et al. “Relationship between bone mineral density and dietary intake of β-carotene, vitamin C, zinc and vegetables in postmenopausal Korean women: a cross-sectional study”. Journal of Internal Medical Research 5 (2016): 1103-1114.
  25. Sun Y., et al. “Dietary vitamin C intake and the risk of hip fracture: a dose-response meta-analysis”. Osteoporosis International 1 (2018): 79-87.
  26. Torbergsen AC.., et al. “Micronutrients and the risk of hip fracture: case-control study”. Clinical Nutrition 2 (2017): 438-443.
  27. Zeng LF., et al. “Can dietary intake of vitamin C-oriented foods reduce the risk of osteoporosis, fracture, and bmd loss? systematic review with meta-analyses of recent studies”. Frontiers of Endocrinology 10 (2020): 844.
  28. Choi NG., et al. “Fall-related emergency department visits and hospitalizations among community-dwelling older adults: examination of health problems and injury characteristics”. BMC Geriatrics 1 (2019): 303.
  29. LeBlanc KE., et al. “Hip fracture: diagnosis, treatment, and secondary prevention”. American Family Physician 12 (2014): 945-951.
  30. Marks R., et al. “Hip fractures among the elderly: causes, consequences and control”. Ageing Research Reviews 1 (2003): 57-93.
  31. Ahmadieh H and Arabi A. “Vitamins and bone health: beyond calcium and vitamin D”. Nutrition Review 10 (2011): 584-598.
  32. Balboa-Castillo T., et al. “Low vitamin intake is associated with risk of frailty in older adults”. Age Ageing 47 (2018): 872-879.
  33. Ballaz SJ. and Rebec GV. “Neurobiology of vitamin C: expanding the focus from antioxidant to endogenous neuromodulator”. Pharmacology Research 146 (2019): 104321.
  34. Lykkesfeldt J and Tveden-Nyborg P. “The pharmacokinetics of vitamin C”. Nutrients 10 (2019): E2412.
  35. Zollinger PE., et al. “Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomized trial”. Lancet 9195 (1999): 2025-2028.
  36. Ojo F., et al. “History of fractures as predictor of subsequent hip and nonhip fractures among older” Mexican Americans”. Journal of the National Medical Association 4 (2007): 412-418.
  37. Liu ZM, et al. “Greater fruit intake was associated with better bone mineral status among Chinese elderly men and women: results of Hong Kong Mr. Os and Ms. Os studies”. Journal of the American Medical Directors Association 4 (2015): 309-315.
  38. Schnitzler C., et al. “Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black african patients with hip fractures - a bone histomorphometric study”. Calcified Tissue International 2 (2005): 79-89.
  39. Lumbers M., et al. “Nutritional status in elderly female hip fracture patients: comparison with an age- matched home living group attending day centres”. British Journal of Nutrition 6 (2001): 733-740.
  40. Nieves JW., et al. “A case-control study of hip fracture: evaluation of selected dietary variables and teenage physical activity”. Osteoporos International 3. (1992): 122-127.
  41. Zhang J., et al. “Antioxidant intake and risk of osteoporotic hip fracture in Utah: an effect modified by smoking status”. American Journal of Epidemiology 163 (2006): 9-17.
  42. Yilmaz C, et al. “The contribution of vitamin C to healing of experimental fractures”. Archives of Orthopaedic and Trauma Surgery 7 (2001): 426-428.
Citation: Ray Marks. “Vitamin C and Hip Fractures-Review”. EC Orthopaedics 11.5 (2020): 33-41.

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