Review Article
Volume 11 Issue 5 - 2020
Basic Orthopedic Immunobiologics
Austin Yeargan*
Regenerative Medicine Clinic, Wilmington, North Carolina, USA
*Corresponding Author: Austin Yeargan, Regenerative Medicine Clinic, Wilmington, North Carolina, USA.
Received: March 18, 2020; Published: April 16, 2020




Abstract

Musculoskeletal biologic therapeutic technologies have emerged as safe, viable, disease modifying options for primary (RA) and secondary (OA) inflammatory arthritis patients who often have had no option other than a potentially complicated surgery with uncertain outcomes. Understanding the basic science of immunologic cell signaling pathways and tissue response will continue to lead to more specific, targeted biologic treatments. We present an easy to follow, infographic that we believe serves as a reasonable baseline to help patients and surgeons understand the principles of biologic treatment in orthopedic surgery and neurosurgery.

Keywords: Knee Arthritis; Orthopedic Surgery; Osteoarthritis; Stem Cells; Signaling Cells; Regenerative Medicine; Arthritis; Knee Pain; Bioloigcs; Neurosurgery; Cartigram; Diffusion Weighted MRI

References

  1. J Hootman and CG Helmick. “Updated Projected Prevalence of Self-Reported Doctor-Diagnosed Arthritis and Arthritis-Attributable Activity Limitation Among US Adults, 2015-2040”. Arthritis and Rheumatology7 (2016): 1582-1587.
  2. JM Hootman and CG Helmick. “Projections of US Prevalence of Arthritis and Associated Activity Limitations”. Arthritis and Rheumatology1 (2006): 226-229.
  3. Stone KR., et al. “Long-term survival of concurrent meniscus allograft transplantation and articular cartilage repair”. Paper #575. Presented at the 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons. New Orleans (2010).
  4. MM Luchetti., et al. “Biologics in Inflammatory and Immunomediated Arthritis”. Current Pharmaceutical Biotechnology12 (2017): 989-1007.
  5. Embrel® (etanercept) is manufactured by Immunex branch of Pfizer® and marketed by Amgen® under the trade name Embrel®.
  6. N Wu., et al. “Cost of Biologics Per Treated Patient Across Immne-Mediated Inflammatory Disease Indications in a Pharmacy Benefit Management Setting: A Retrospective Cohort Study”. Clinical Therapeutics8 (2014): 1231-1241.
  7. AS Wei., et al. “The Effect of Corticosteroid on Collagen Expression in Injured Rotator Cuff Tendon”. Journal of Bone and Joint Surgery6 (2006): 1331-1338.
  8. J Choi and G Gold. “MR Imaging of Articular Cartilage Physiology”. Magnetic Resonance Imaging Clinics of North America2 (2011): 249-282.
  9. FJ Bianco., et al. “Osteoarthritis chondrocytes die by apoptosis: A possible pathway for osteoarthritis pathology”. Arthritis and Rheumatology2 (1999): 284-289.
  10. LT Moti and HE Sabaawy. “Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention”. Therapeutic Advances in Musculoskeletal Disease3 (2015): 76-87.
  11. CJ Centeno., et al. “Increased knee cartilage volume in degenerative joint disease using percutaneously implanted autologous mesenchymal stem cells”. Pain Physician3 (2008): 343-353.
  12. Laura Dyrda. “Orthopedic and Spine Industry Leader To Know: Dr. Austin Yeargan of North Carolina Shoulder and Elbow Surgery” (2010).
  13. AAOC.
Citation: Austin Yeargan. “Basic Orthopedic Immunobiologics”. EC Orthopaedics 11.5 (2020): 07-15.

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