Mini Review
Volume 11 Issue 4 - 2020
Circulatory Biomarkers of Osteosarcoma: A Review
Pulak Sharma1, Ajai Singh2*, Salma Siddiqui2 and Sabir Ali2
1Trauma Center, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
2Department of Paediatric Orthopaedic, King George’s Medical University, Lucknow, Uttar Pradesh, India
*Corresponding Author: Ajai Singh, Professor and Head, Department of Paediatric Orthopaedic, King George’s Medical University, Lucknow, Uttar Pradesh, India.
Received: February 18, 2020; Published: March 10, 2020


Osteosarcoma is a complex disease with various biological and clinical dissimilarities that further complicates the management as well as prognosis disease. Higher mortality and morbidity rate is also associated, because of late diagnosis, metastasis, due to chemo resistant and non-availability of alternative treatment. The clinic-radiological examinations having their own limitations and could not able to discriminate the micro changes due to treatment at an early stage. This mini review focused on the utility of biomarkers along with their advantages over conventional therapy of osteosarcoma. Till date, numerous fundamental, translational and clinical studies have acknowledged various biomarkers related to osteosarcoma. Furthermore, accomplishing the translating knowledge of biomarkers from benchside to bedside needs prudently distinct preclinical studies and randomized controlled studies.

Keywords: Osteosarcoma; Biomarkers; Diagnostic; Prognostic


  1. Durfee RA., et al. “Review of osteosarcoma and current management”. Rheumatology and Therapy 3.2 (2016): 221-243.
  2. Link MP., et al. “Pediatric oncology: osteosarcoma”. Principles and Practice of Pediatric Oncology (1989): 689-711.
  3. Bielack SS., et al. “Osteosarcoma, in Cancer in Children: Clinical Management”. 5th Edition (New York, NY: Oxford University Press) (2005).
  4. Luetke A., et al. “Osteosarcoma treatment-where do we stand? A state of the art review”. Cancer Treatment Reviews 40.2 (2014): 523-532.
  5. Kundu ZS. “Classification, imaging, biopsy and staging of osteosarcoma”. Indian Journal of Orthopaedics 48.3 (2014): 238.
  6. Ottaviani G., et al. “The epidemiology of osteosarcoma”. In Pediatric and adolescent osteosarcoma (2009): 3-13. 
  7. Bielack SS., et al. “Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols”. Journal of Clinical Oncology 20 (2002): 776-790. 
  8. Eccles SA., et al. “Metastasis: recent discoveries and novel treatment strategies”. Lancet 369 (2007): 1742-1757. 
  9. Ren L., et al. “Characterization of the metastatic phenotype of a panel of established osteosarcoma cells”. Oncotarget 6 (2015): 29469-29481. 
  10. Bernthal NM., et al. “Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma”. Cancer 118 (2012): 5888-5893. 
  11. Arnott J A., et al. “CCN Family: Matricellular Proteins in Cartilage and Bone Development”. In Composition and Function of the Extracellular Matrix in the Human Body (2016): 161. 
  12. Wadhwa N. “Osteosarcoma: diagnostic dilemmas in histopathology and prognostic factors”. Indian Journal of Orthopaedics 48.3 (2014): 247.
  13. Dadia S., et al. “Characteristics, diagnosis and treatment of bone and soft tissue sarcomas”. British Journal of Hospital Medicine 68.11 (2007): 589-593.
  14. Chou AJ., et al. “Treatment of osteosarcoma at first recurrence after contemporary therapy: the Memorial Sloan-Kettering Cancer Center experience”. Cancer 104.10 (2005): 2214-2221. 
  15. Daw NC., et al. “Metastatic osteosarcoma”. Cancer 106.2 (2006): 403-412. 
  16. Zamborsky R., et al. “Identification of prognostic and predictive osteosarcoma biomarkers”. Medical Sciences 7.2 (2019): 28.
Citation: Ajai al. “Circulatory Biomarkers of Osteosarcoma: A Review”. EC Orthopaedics 11.4 (2020): 18-20.

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