Case Series
Volume 11 Issue 4 - 2020
A Case Series of Cervical Disc Disease Pain Relieved by New Five Injection Spots of Lignocaine (The Anatomical Gates of Sodium Channels Blockers of the Upper Limbs)
Amjid Hammodi*
Orthopaedic Surgeon, Baghdad, Iraq
*Corresponding Author: Amjid Hammodi, Orthopaedic Surgeon, Baghdad, Iraq.
Received: February 14, 2020; Published: March 09, 2020




Abstract

Background: This case series describes for the first time five injection spots of lignocaine only without steroids which relieve pain related to cervical spine disc disease. The injection spots are called gates and they are part of the anatomical gates of sodium channels blockers discovered by the author. These gates are M, A, H, O and B. Lignocaine is a sodium channel blocker and when it is used in these special gates it resets the disturbance in sodium channels of nerves which is the cause of pain as documented in many published studies and thus lignocaine acts as a therapeutic drug and will give long duration pain relief for months.

These gates injections are given distal to the cervical spine and the author hypothesized that the lignocaine which is a lipid soluble drug will diffuse through the myelin sheath of nerves which is mainly formed of lipids itself and that diffusion could reach, up to a limit, different nerves if they share continuous non interrupted myelin sheath and throughout that diffusion it will cause resetting of sodium channels and the relief of pain.

Gates A and B are already published and this case series will describe the other three gates for the first time.

Case Presentation: Five patients with variable presenting symptoms of cervical disc disease, different duration of symptoms and of different age groups were injected each in one of the gates injection M, A, H, O and B and all patients described pain relief which lasted more than three months post the injections.

Conclusion: These gates injections of lignocaine only which is a sodium channel blocker will give durable pain relief for months in patients with severe pain related to the cervical spine disc disease and will be very effective in reducing operations on the cervical spine knowing that the surgery of the cervical spine is done in 90% of cases to control pain not controllable by conservative management.

Also, these injections use no steroids and are free of the serious risks related to cervical epidural steroids injections which are not FDA approved. Also, these injections require less training and are easier to perform and they require no theatre setting, no ultrasound and no x-ray guidance.

Keywords: Cervical Disc Disease; Cervicobrachial Pain; Upper Limb Radiculopathy; Neck Pain; The Anatomical Gates of Sodium Channels Blockers

References

  1. Roujian Lu., et al. “Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding”. The Lancet 395.10224 (2020): 565-574.
  2. Luo Y., et al. “Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang”. Hypertension Research 42.5 (2019): 681-689.
  3. Wang SX., et al. “Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy”. Chinese Medical Journal 121.1 (2008): 27-31.
  4. https://www.snpedia.com/index.php/Rs6632677?fbclid=IwAR3G_5wNAuu5DAaGD5WXfoPzClIzOTchrwSscUTJnufMon6bTPJck8wZQxM
  5. WHO. Consensus document on the epidemiology of severe acute respiratory syndrome (SARS).
  6. Peiris JS., et al. “Severe acute respiratory syndrome”. Nature Medicine 10.12 (2004): S88-S97. 
  7. Zhou P., et al. “Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin”. bioRxiv (2020). 
  8. Kumar A., et al. “ACE2, CALM3 and TNNI3K polymorphisms as potential disease modifiers in hypertrophic and dilated cardiomyopathies”. Molecular and Cellular Biochemistry 450.1-2 (2019): 209-210.
  9. Feng W., et al. “Association of AGTR1 and ACE2 gene polymorphisms with structural atrial fibrillation in a Chinese Han population”. Pharmazie 72.1 (2017): 17-21.
  10. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. The Lancet 395.10223 (2020): 497-506. 
  11. Na Zhu., et al. “A Novel Coronavirus from Patients with Pneumonia in China, 2019”. New England Journal of Medicine 382.8 (2020): 727-733.
  12. The 2019 Novel Coronavirus Outbreak – Update From NIAID’s Anthony Fauci, MD (2020).
  13. Yicheng Fang., et al. “CT Manifestations of Two Cases of 2019 Novel Coronavirus (2019-nCoV) Pneumonia”. Radiology (2020).
  14. “Coronavirus disease 2019 (COVID-19) WHO”. 
  15. Emmie de Wit., et al. “Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection”. Proceedings of the National Academy of Sciences of the United States of America (2020).
  16. https://www.researchgate.net/figure/The-life-cycle-of-SARS-CoV-and-MERS-CoV-in-host-cells-SARS-CoV-and-MERS-CoV-enter-target_fig1_330374659
  17. College of Science Technology and Medicine, London.
  18. Catherine Offord, Feb 21, 2020 How COVID-19 Is Spread. 
  19. Yanan Cao., et al. “Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations”. Nature (2020).
Citation: Amjid Hammodi. “A Case Series of Cervical Disc Disease Pain Relieved by New Five Injection Spots of Lignocaine (The Anatomical Gates of Sodium Channels Blockers of the Upper Limbs)”. EC Orthopaedics 11.4 (2020): 06-17.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


December Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before December 20, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.