Review Article
Volume 11 Issue 2 - 2020
Magnetic Resonance Cartigram Sequencing in the Setting of Autologous Orthopedic Immunobiologics
Austin Yeargan* and Brittany LaRussa
Regenerative Medicine Clinic, Wilmington, North Carolina, USA
*Corresponding Author: Austin Yeargan, Regenerative Medicine Clinic, Wilmington, North Carolina, USA.
Received: December 26, 2019; Published: January 23, 2020




Abstract

Magnetic resonance Cartigram® T2 wetmap sequencing (General Electric®, Chicago, IL) has the capability to diagnose appendicular degenerative joint disease with greater sensitivity and specificity than any other imaging modality. This diagnostic advantage has become particularly advantageous with the advancement of autologous orthopedic immunobiologics (AOI) in the orthopedic surgery over the last decade. No studies have been published where diffusion weighted sequences have been used in the setting of autologous biologic therapeutics. T2 wetmapping studies may perfectly compliment the screening process in orthopedic and neurosurgical patients who could be candidates for signaling cell procedures. 

The imaging sequences are enabled by the natural metabolic consequences of the degenerative processes that occur during the biological life of human connective tissues. Proteoglycan is the major shock absorbing protein in joint cartilage and the spinal disks and has been likened to a sponge retaining water. The T2 wetmap sequences provide additional information concerning degenerative neurologic disease, metabolic musculoskeletal disease and degenerative orthopedic disease. Each of these can be identified earliest with T2 wetmap sequencing when combined with routine MR sequencing. In the setting of central nervous system disease, Apparent diffusion coefficient (ADC) and diffusion weighted imaging (DWI) sequences provide similar advantages to routine MR imaging and costs are negligible compared to the clinical advantage to the patient. Wetmap imaging has the power to define disease earliest when conservative measures are most likely to stop the advancement of the pathological process and even reverse it. Arthritis is a mechanically induced disease with sinister molecular consequences that are best visualized with wetmap sequencing. We review our clinical algorithm for management of patients with osteoarthritis who seek signaling cell-based treatments. 

Keywords: MR Sequencing; Apparent Diffusion Coefficient (ADC); Diffusion Weighted Imaging (DWI); Orthopedic Immunobiologics

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Citation: Austin Yeargan and Brittany LaRussa. “Magnetic Resonance Cartigram Sequencing in the Setting of Autologous Orthopedic Immunobiologics”. EC Orthopaedics 11.2 (2020): 01-10.

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