Short Communication
Volume 13 Issue 5 - 2022
Updates on Pharmacotherapy of Diabetic Retinopathy
Marianne L Shahsuvaryan*
Professor, Department of Ophthalmology, Yerevan State Medical University, Yerevan, Armenia
*Corresponding Author: Marianne L Shahsuvaryan, Professor, Department of Ophthalmology, Yerevan State Medical University, Yerevan, Armenia.
Received: April 29, 2022; Published: May 27, 2022




Abstract

“Pandemy” of diabetes mellitus is recorded worldwide [1]. It’s hard to overstate just how big of a problem diabetes is and is projected to be in the future. The incidence and prevalence of diabetes and diabetic retinopathy, as the most common microvascular complication of diabetes, is exponentially growing due to increased life expectancy in many parts of the world. Diabetic retinopathy (DR) is a visually disabling disease affecting the retina and representing a major cause of vision loss and even blindness [2], which currently is characterized as a neurovasculopathy. The forecast for the year 2040 indicates that the number of patients with diabetic retinopathy will reach 224 million [3].

References

  1. Namperumalsamy P. “Hope insight”. Journal of Ophthalmology Clinics and Research1 (2021): 3-6.
  2. Yao X., et al. “Distribution of diabetic retinopathy in diabetes mellitus patients and its association rules with other eye diseases”. Scientific Reports 1 (2021): 16993.
  3. “Strengthening diagnosis and treatment of diabetic retinopathy in the South-East Asia Region”. New Delhi: World Health Organization, Regional Office for South-East Asia. Licence: CC BY-NC-SA 3.0 IGO (2020).
  4. Cignarella A., et al. “Clinical efficacy and safety of angiogenesis inhibitors: sex differences and current challenges”. Cardiovascular Research4 (2022): 988-1003.
  5. Xie H., et al. “The fundus structural and functional predictions of DME patients after anti-VEGF treatments”. Frontiers in Endocrinology 13 (2022): 865211.
  6. Simó R., et al. “Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy”. Pharmaceutics8 (2021): 1320.
  7. Oshitari T. “Neurovascular Impairment and Therapeutic Strategies in Diabetic Retinopathy”. International Journal of Environmental Research and Public Health1 (2022): 439.
  8. Antonetti DA., et al. “Current understanding of the molecular and cellular pathology of diabetic retinopathy”. Nature Reviews Endocrinology4 (2021): 195-206.
  9. Rajagopal R. “Fenofibrate reduces the severity of neuroretinopathy in a type 2 model of diabetes without inducing peroxisome proliferator-activated receptor alpha-dependent retinal gene expression”. Journal of Clinical Medicine1 (2020): 126.
  10. Lee D., et al. “Pemafibrate prevents retinal dysfunction in a mouse model of unilateral common carotid artery occlusion”. International Journal of Molecular Sciences17 (2021): 9408.
  11. Lee D., et al. “Fenofibrate protects against retinal dysfunction in a murine model of common carotid artery occlusion-induced ocular ischemia”. Pharmaceuticals3 (2021): 223.
  12. Hanaguri J., et al. “Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice”. Pharmaceutics2 (2022): 384.
  13. Keech AC., et al. “Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial”. The Lancet9600 (2007): 1687-1697.
  14. ACCORD Study Group and ACCORD Eye Study Group. “Effects of medical therapies on retinopathy progression in type 2 diabetes”. New England Journal of Medicine3 (2010): 233-244.
  15. Souto EB., et al. “Nanoparticle delivery systems in the treatment of diabetes complications”. Molecules23 (2019): 4209.
Citation: Marianne L Shahsuvaryan. “Updates on Pharmacotherapy of Diabetic Retinopathy”. EC Ophthalmology 13.5 (2022): 40-42.

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