Research Article
Volume 12 Issue 4 - 2021
Vaccines and Corneal Graft Rejection
Frederick T Fraunfelder1 and Frederick W Fraunfelder2*
1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA
2Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA
*Corresponding Author: Frederick W Fraunfelder, Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, One Hospital Drive, Columbia, Missouri, USA.
Received: February 18, 2021; Published: March 31, 2021


A retrospective case series to report a possible signal between vaccinations and corneal graft rejection (CGR). Post-marketing drug surveillance were reviewed for possible vaccine related CGR. In addition, a literature search using “vaccine” and “corneal graft rejection” was performed. Global online medical and life sciences media services were also reviewed. There were 25 possible vaccine related CGR in 22 eyes of 19 patients. Median age was 67 years. Onset post-vaccination to CGR had a median of 14 days. There were 3 positive rechallenges with a median time to onset of 14 days and 1 positive double rechallenge. There were 3 bilateral CGR with 2 occurring in both eyes within 24 hours after vaccination and 1 second eye CGR occurring within 72 hours of the first eye. Nineteen eyes recovered with steroids, 3 went on to graft failure, and there was no follow-up data in the remaining 3 cases. This data suggests a signal that requires future large data analysis to determine if, in a small subset of patients, vaccines may cause CGR. Ophthalmologists may consider asking CGR patients about their last 2-month vaccination history. Prophylactic steroids may be considered in these patients when future vaccinations occur.


Keywords: Vaccine; Vaccination; Corneal Graft Rejection; Corneal Graft Failure


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Citation: Frederick T Fraunfelder and Frederick W Fraunfelder. “Vaccines and Corneal Graft Rejection”. EC Ophthalmology 12.4 (2021): 36-41.

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