Research Article
Volume 12 Issue 2 - 2021
Effects of Isoflurane and Midazolam on Tear Production and Intraocular Pressure in Capuchin Monkeys (Sapajus libidinosus)
Paula Diniz Galera1*, Ricardo Miyasaka de Almeida1, Cecília Azevedo Dias Lopes2, Layla Karolaynne Souza Cruz3 and Fabiano Montiani-Ferreira4
1College of Agronomy and Veterinary Medicine, University of Brasília, Brasilia, DF, Brazil
2College of Veterinary Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, DF, Brazil
3Autonomous Veterinary, Brasilia, DF, Brazil
4Department of Veterinary Medicine, Federal University of Paraná, PR, Brazil
*Corresponding Author: Paula Diniz Galera, College of Agronomy and Veterinary Medicine, University of Brasília, Brasilia, DF, Brazil.
Received: December 16, 2020; Published: January 30, 2021


Background: Anesthetics may be necessary for ophthalmic examination in capuchin monkeys and may affect the intraocular pressure (IOP) or aqueous tear production; therefore, these may be of concern when performing these evaluations.

Aim: To evaluate the influence of isoflurane alone, or combined with midazolam, on tear production by STT and on IOP by applanation and rebound tonometry in S. libidinosus.

Methods: Thirty-eight monkeys received isoflurane (n = 16), midazolam-isoflurane (n = 12), or physical restraint (control; n = 10) for evaluation of aqueous tear production (STT) and IOP (applanation or rebound tonometry).

Results: Anesthesia lowered STT values. Isoflurane was not significantly different compared to midazolam-isoflurane (P = 0.59) or control (P = 0.06); however, STT was significantly more reduced in midazolam-isoflurane compared to control (P = 0.01). IOP showed no significant differences among groups (P > 0.05), but rebound tonometry resulted in higher IOP values when compared to applanation tonometry values (P = 0.02). There were no significant differences in STT and IOP between right and left eyes or between males and females (P > 0.05).

Conclusion: Midazolam-isoflurane reduced aqueous tear production; however, IOP was not affected by either restraint protocol.

Keywords: Anesthesia; Intraocular Pressure; Monkey; Primate; Schirmer Tear Test


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Citation: Paula Diniz Galera., et al. “Effects of Isoflurane and Midazolam on Tear Production and Intraocular Pressure in Capuchin Monkeys (Sapajus libidinosus)”. EC Ophthalmology 12.2 (2021): 47-54.

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