Research Article
Volume 11 Issue 12 - 2020
Efficacy of Topical Cyclosporine in the Treatment of Atopic and Vernal Keratoconjunctivitis
Maria Akhtar Dalia1, Mohammad Kumruzzaman Sarker1, Md Zainal Abedin1, Mahfuz-Ul-Anwar1, Moni Rani2 and Ratindra Nath Mondal3*
1Rangpur Medical College, Rangpur, Bangladesh
2Rajshahi Medical College, Rajshahi, Bangladesh
3Society of General Physicians and Daktarkhana (GP Center), Rangpur, Bangladesh
*Corresponding Author: Ratindra Nath Mondal, Society of General Physicians and Daktarkhana (GP Center), Rangpur, Bangladesh.
Received: September 28, 2020; Published: November 07, 2020


Background: Atopic and vernal keratoconjunctivitis can be treated with a variety of medications, including topical antihistamines, mast cell stabilizers, nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. But none proven to be effective and safe for long term use.

Methods: An intervention study was conducted on 70 atopic and 70 vernal keratoconjunctivitis patients in NIO&H Dhaka during the period of August 2010 to January 2011. All the subjects received topical cyclosporine 0.05%. 20 patients were lost to follow up and remaining 120 patients’ (60 patients were atopic and 60 patients were vernal keratoconjunctivitis) data was analyzed.

Result: Mean age of the vernal and atopic keratoconjunctivitis mean age were 7.32 ± 3.52 (SD) and 32.07 ± 9.80 respectively. In both the group male were more than female (VKC male vs female 73.3% vs 23.7%, AKC 53.3% vs 46.7%). At the baseline, 100% of the vernal and atopic keratoconjunctivitis patients had itching, discharge, redness and irritation. Photophobia was more in vernal keratoconjunctivitis 40% than atopic keratoconjunctivitis 6.7% (p < 0.001). Allergy was more common in atopic keratoconjunctivitis (93.3%) than vernal keratoconjunctivitis (46.7%) (p < 0.001). Co-existence of asthma was equal in atopic and veneral keratoconjunctivitis 40%), but eczema was more in atopic keratoconjunctivitis patients 93.3% than veneral atopic keratoconjunctivitis patients 18.3% (p < 0.001).

After 15 days of treatment, lacrimation status improved in 93.3% of atopic and 60% of veneral keratoconjunctivitis patients. There was no significant improvement of other symptoms after 15 days and 1 month. After completion of 3 months treatment 93.3% patients improved in case of atopic keratoconjunctivitis and 91% in vernal keratoconjunctivitis.

Conclusion: In our study topical cyclosporine 0.05% was found effective in both atopic and vernal keratoconjunctivitis.

Keywords: Cyclosporine; Atopic; Vernal; Keratoconjunctivitis


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Citation: Ratindra Nath Mondal., et al. “Efficacy of Topical Cyclosporine in the Treatment of Atopic and Vernal Keratoconjunctivitis”. EC Ophthalmology 11.12 (2020): 01-08.

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